Prevalence of Cardiac Amyloidosis in Patients with Carpal Tunnel Syndrome

被引：36

作者：

Zegri-Reiriz, Isabel ^{[1
]}

Javier de Haro-del Moral, F. ^{[2
]}

Dominguez, Fernando ^{[1
,3
,4
]}

Salas, Clara ^{[3
,5
]}

de la Cuadra, Pablo ^{[6
]}

Plaza, Aresio ^{[7
]}

Krsnik, Isabel ^{[8
]}

Gonzalez-Lopez, Esther ^{[1
,3
,4
]}

Garcia-Pavia, Pablo ^{[1
,3
,9
]}

机构：

[1] Hosp Univ Puerta Hierro, Dept Cardiol, Manuel Falla 2, Madrid 28222, Spain

[2] Hosp Univ Puerta Hierro, Dept Nucl Med, Madrid, Spain

[3] CIBER Cardiovasc Dis CIBERCV, Madrid, Spain

[4] CNIC, Myocardial Biol Programme, Madrid, Spain

[5] Hosp Univ Puerta Hierro, Dept Pathol, Madrid, Spain

[6] Hosp Univ Puerta Hierro, Dept Orthopaed & Traumatol, Madrid, Spain

[7] Hosp Univ Puerta Hierro, Dept Immunol, Madrid, Spain

[8] Hosp Univ Puerta Hierro, Dept Hematol, Madrid, Spain

[9] UFV, Madrid, Spain

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2019年 / 12卷 / 06期

关键词：

Amyloidosis; Tansthyretin; Carpal tunnel syndrome; TRANSTHYRETIN; DIAGNOSIS;

D O I：

10.1007/s12265-019-09895-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Carpal tunnel syndrome (CTS) is a common finding among patients with cardiac amyloidosis. We sought to determine the prevalence of cardiac amyloidosis in patients who had undergone CTS surgery. From 2005 to 2014, 308 patients >= 60 years underwent CTS surgery. Of these, 233 (76%) agreed to participate in the study and 101 (73 +/- 8 years; 68% females) showed left ventricular hypertrophy (LVH) >= 12 mm and underwent additional studies to diagnose AL and ATTR amyloidosis. Based on complementary studies, three patients were diagnosed with cardiac amyloidosis (two wild-type ATTR and one AL). The three patients showed bilateral CTS with no occupational risk factors. Prevalence of cardiac amyloidosis in the overall cohort was only 1.2% (3/233), but among patients with LVH and bilateral CTS, the prevalence was 5.5% (3/55) and 13.6% (3/22) if cases with an occupational risk factor were excluded. Cardiac amyloidosis should be excluded in the presence of bilateral CTS and particularly if an occupational risk factor is absent.

引用

页码：507 / 513

页数：7

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