Transcriptional dysregulation in Huntington's disease

被引:324
作者
Cha, JHJ [1 ]
机构
[1] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA
关键词
D O I
10.1016/S0166-2236(00)01609-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Although the gene responsible for Huntington's disease was discovered in 1993, the pathogenic mechanisms by which mutant huntingtin causes neuronal dysfunction and death remain unclear. However, increasing evidence suggests that mutant huntingtin disrupts the normal transcriptional program of susceptible neurons. Thus, transcriptional dysregulation might be an important pathogenic mechanism in Huntington's disease.
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收藏
页码:387 / 392
页数:6
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