Luteolin attenuated cisplatin-induced cardiac dysfunction and oxidative stress via modulation of Keap1/Nrf2 signaling pathway

被引：14

作者：

Qi, Yajun ^{[1
,2
]}

Fu, Shuang ^{[3
,4
]}

Pei, Donggen ^{[5
]}

Fang, Qilu ^{[1
,2
]}

Xin, Wenxiu ^{[1
,2
]}

Yuan, Xiaohong ^{[3
,4
]}

Cao, Yingying ^{[1
,2
]}

Shu, Qi ^{[1
,2
]}

Mi, Xiufang ^{[1
,2
]}

Luo, Fang ^{[1
,2
]}

机构：

[1] Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Pharm, 38 Guangji Rd, Hangzhou 310022, Zhejiang, Peoples R China

[2] Chinese Acad Sci, Inst Canc & Basic Med IBMC, Dept Pharm, Hangzhou, Zhejiang, Peoples R China

[3] Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Anesthesiol, Hangzhou, Zhejiang, Peoples R China

[4] Chinese Acad Sci, Inst Canc & Basic Med IBMC, Dept Anesthesiol, Hangzhou, Zhejiang, Peoples R China

[5] Nanjing Med Univ, Childrens Hosp, Dept Pharm, Nanjing, Peoples R China

来源：

FREE RADICAL RESEARCH | 2022年 / 56卷 / 02期

关键词：

Luteolin; cisplatin; oxidative stress; Keap1; Nrf2; INDUCED CARDIOTOXICITY; NRF2; PROGRESSION; MECHANISMS; INJURY; AMPK;

D O I：

10.1080/10715762.2022.2067042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cardiovascular complications are a well-documented limitation of cancer chemotherapy. Cisplatin-induced cardiotoxicity threatens the health and life of patients, and limits the application of cisplatin. Oxidative stress is the main mechanism underlying cisplatin-induced cardiac toxicity. Luteolin (Lut) has been reported to possess cardioprotective properties by activating nuclear factor-E2-related factor 2 (Nrf2) -mediated antioxidant response. However, the effect of Lut on cisplatin-induced cardiac damage remains unclear. In this study, we revealed that Lut exerted a protective effect against cisplatin-induced cardiac dysfunction and injury in vivo. In HL-1 cells, Lut was observed to dramatically reduce cisplatin-induced apoptosis and oxidative stress by modulating the Kelch-like epichlorohydrin-associated protein 1 (Keap1)/Nrf2 pathway. Altogether, these findings suggested that Lut showed promise in attenuating cisplatin-induced cardiac injury and might be considered a protective drug candidate for chemotherapy-associated cardiovascular complications.

引用

页码：209 / 221

页数：13

共 42 条

[1] Propionyl-L-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model [J].