Overview of Silk Fibroin Use in Wound Dressings

被引：361

作者：

Farokhi, Mehdi ^{[1
]}

Mottaghitalab, Fatemeh ^{[2
]}

Fatahi, Yousef ^{[3
]}

Khademhosseini, Ali ^{[4
]}

Kaplan, David L. ^{[5
]}

机构：

[1] Pasteur Inst Iran, Natl Cell Bank Iran, Tehran, Iran

[2] Univ Tehran Med Sci, Fac Pharm, Nanotechnol Res Ctr, Tehran, Iran

[3] Univ Tehran Med Sci, Fac Pharm, Dept Pharmaceut Nanotechnol, Tehran, Iran

[4] Univ Calif Los Angeles, Calif Nanosyst Inst, Dept Radiol, Dept Chem & Biomol Engn,Dept Bioengn, Los Angeles, CA USA

[5] Tufts Univ, Dept Biomed Engn, Medford, MA 02155 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2018年 / 36卷 / 09期

关键词：

EPIDERMAL-GROWTH-FACTOR; VENOUS LEG ULCERS; SKIN SUBSTITUTES; SILVER NANOPARTICLES; ALGINATE DIALDEHYDE; ASTRAGALOSIDE IV; IN-VITRO; KAPPA-B; NANOFIBERS; SCAFFOLDS;

D O I：

10.1016/j.tibtech.2018.04.004

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Recently, biomimetic wound dressings were introduced as potential replacements for treating skin injuries. Although there are some clinically available skin replacements, the range of wound types and locations necessitates a broader range of options for the clinic. Natural polymeric-based dressings are of central interest in this area due to their outstanding biocompatibility, biodegradability, low toxicity, and non-allergenic nature. Among them, silk fibroin (SF) has exceptional characteristics as a wound dressing. SF-based dressings can also be used as carriers for delivering drugs, growth factors, and bioactive agents to the wound area, while providing appropriate support for complete healing. In this review, we describe recent advances in the development of SF-based wound dressings for skin regeneration.

引用

页码：907 / 922

页数：16

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