Salvinorin A: the 'magic mint' hallucinogen finds a molecular target in the kappa opioid receptor

被引：119
|
作者：
Sheffler, DJ
Roth, BL
机构：
[1] Case Western Reserve Univ, Sch Med, Natl Inst Mental Hlth, Psychoact Drug Screening Program, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Sch Med, Dept Psychiat, Cleveland, OH 44106 USA
[4] Case Western Reserve Univ, Sch Med, Dept Neurosci, Cleveland, OH 44106 USA
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2003年 / 24卷 / 03期
关键词：
D O I：
10.1016/S0165-6147(03)00027-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Salvinorin A, a neoclerodane diterpene, is the most potent naturally occurring hallucinogen known and rivals the synthetic hallucinogen lysergic acid diethylamide in potency. Recently, the molecular target of salvinorin A was identified as the kappa opioid receptor (KOR). Salvinorin A represents the only known non-nitrogenous KOR selective agonist. Based on the selectivity of salvinorin A for the KOR, this receptor represents a potential molecular target for the development of drugs to treat disorders characterized by alterations in perception, including schizophrenia, Alzheimer's disease and bipolar disorder.
引用
收藏
页码：107 / 109
页数：3
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