Unravelling how glucocorticoids work in rheumatoid arthritis

被引：11

作者：

Hardy, Rowan ^{[1
]}

Cooper, Mark S. ^{[2
]}

机构：

[1] Univ Birmingham, Inst Metab & Syst Res, Birmingham, W Midlands, England

[2] Univ Sydney, Concord Clin Sch, ANZAC Res Inst, Sydney, NSW, Australia

来源：

NATURE REVIEWS RHEUMATOLOGY | 2018年 / 14卷 / 10期

基金：

英国医学研究理事会;

关键词：

DEHYDROGENASE TYPE-1; RECEPTOR; THERAPY;

D O I：

10.1038/s41584-018-0079-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Using mice with targeted deletion of the glucocorticoid receptor, a new study has examined the cell types that mediate the anti-arthritic effects of therapeutic glucocorticoids. Surprisingly, in the serum transfer-induced arthritis model, glucocorticoids target stromal cells rather than immune cells.

引用

页码：566 / 567

页数：3

共 10 条

[1] Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells [J].

Baschant, Ulrike ;

Frappart, Lucien ;

Rauchhaus, Una ;

Bruns, Lisa ;

Reichardt, Holger M. ;

Kamradt, Thomas ;

Braeuer, Rolf ;

Tuckermann, Jan P. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (48) :19317-19322

[2] Transgenic Disruption of Glucocorticoid Signaling in Mature Osteoblasts and Osteocytes Attenuates K/BxN Mouse Serum-Induced Arthritis In Vivo [J].

Buttgereit, Frank ;

Zhou, Hong ;

Kalak, Robert ;

Gaber, Timo ;

Spies, Cornelia M. ;

Huscher, Doerte ;

Straub, Ranier H. ;

Modzelewski, James ;

Dunstan, Colin R. ;

Seibel, Markus J. .

ARTHRITIS AND RHEUMATISM, 2009, 60 (07) :1998-2007

[3] Selective Glucocorticoid Receptor Agonists: Glucocorticoid Therapy With No Regrets? [J].

Cooper, Mark S. ;

Zhou, Hong ;

Seibel, Markus J. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2012, 27 (11) :2238-2241

[4] 11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice [J].

Coutinho, Agnes E. ;

Gray, Mohini ;

Brownstein, David G. ;

Salter, Donald M. ;

Sawatzky, Deborah A. ;

Clay, Spike ;

Gilmour, James S. ;

Seckl, Jonathan R. ;

Savill, John S. ;

Chapman, Karen E. .

ENDOCRINOLOGY, 2012, 153 (01) :234-240

[5] 11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis [J].

Hardy, R. S. ;

Fenton, C. ;

Croft, A. P. ;

Naylor, A. J. ;

Begum, R. ;

Desanti, G. ;

Buckley, C. D. ;

Lavery, G. ;

Cooper, M. S. ;

Raza, K. .

JOURNAL OF AUTOIMMUNITY, 2018, 92 :104-113

[6] Glucocorticoids and Bone: Consequences of Endogenous and Exogenous Excess and Replacement Therapy [J].

Hardy, Rowan S. ;

Zhou, Hong ;

Seibel, Markus J. ;

Cooper, Mark S. .

ENDOCRINE REVIEWS, 2018, 39 (05) :519-548

[7]

Koenen M., 2018, ANN RHEUM DIS, DOI [10.1136/annrheumdls-2017-212762, DOI 10.1136/ANNRHEUMDLS-2017-212762]

[8] Endogenous glucocorticoid signaling in chondrocytes attenuates joint inflammation and damage [J].

Tu, Jinwen ;

Stoner, Shihani ;

Fromm, Phillip D. ;

Wang, Tingyu ;

Chen, Di ;

Tuckermann, Jan ;

Cooper, Mark S. ;

Seibel, Markus J. ;

Zhou, Hong .

FASEB JOURNAL, 2018, 32 (01) :478-487

[9] Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy [J].

Tuckermann, Jan P. ;

Kleiman, Anna ;

Moriggl, Richard ;

Spanbroek, Rainer ;

Neumann, Anita ;

Illing, Anett ;

Clausen, Bjoern E. ;

Stride, Brenda ;

Foerster, Irmgard ;

Habenicht, Andreas J. R. ;

Reichardt, Holger M. ;

Tronche, Francois ;

Schmid, Wolfgang ;

Schuetz, Guenther .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (05) :1381-1390

[10] Macrophage 11β-HSD-1 deficiency promotes inflammatory angiogenesis [J].

Zhang, Zhenguang ;

Coutinho, Agnes E. ;

Man, Tak Yung ;

Kipari, Tiina M. J. ;

Hadoke, Patrick W. F. ;

Salter, Donald M. ;

Seckl, Jonathan R. ;

Chapman, Karen E. .

JOURNAL OF ENDOCRINOLOGY, 2017, 234 (03) :291-299

← 1 →