Long non-coding RNAs in endometrial physiology and pathophysiology

被引：15
作者：
Aljubran, Fatimah [1 ]
Nothnick, Warren B. [1 ,2 ,3 ]
机构：
[1] Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66103 USA
[2] Univ Kansas, Med Ctr, Dept Obstet & Gynecol, Kansas City, KS 66103 USA
[3] Univ Kansas, Med Ctr, Ctr Reprod Sci, Inst Reprod & Perinatal Res, Kansas City, KS 66103 USA
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2021年 / 525卷
关键词：
Endometrium; Endometriosis; Endometrial cancer; Pregnancy; Infertility; Preeclampsia; Non-coding RNAs; CANCER-CELL PROLIFERATION; H19; LNCRNA; IMPLANTATION FAILURE; C-MET; EXPRESSION; GENE; DECIDUALIZATION; CARCINOMA; PTEN; PROGESTERONE;
D O I：
10.1016/j.mce.2021.111190
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The endometrium is an essential component of the female uterus which provides the environment for pregnancy establishment and maintenance. Abnormalities of the endometrium not only lead to difficulties in establishing and maintaining pregnancy but also play a causative role in diseases of endometrial origin including endometriosis and endometrial cancer. Non-coding RNAs are proposed to play a role in regulating the genome in both normal endometrial physiology and pathophysiology. In this review, we first provide a general overview of non-coding RNAs and reproductive physiology of the endometrium. We then discuss the role on non-coding RNAs in normal endometrial physiology and pathophysiology of endometrial infertility. We then conclude with non-coding RNAs in the pathophysiology of endometriosis and endometrial cancer.
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页数：9
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