Control of metabolism by p53-Cancer and beyond

被引：141

作者：

Labuschagne, Christiaan F. ^{[1
]}

Zani, Fabio ^{[1
]}

Vousden, Karen H. ^{[1
]}

机构：

[1] Francis Crick Inst, 1 Midland Rd, London NW1 1AT, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2018年 / 1870卷 / 01期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

P53-MEDIATED TUMOR SUPPRESSION; PANCREATIC BETA-CELLS; FATTY-ACID OXIDATION; DIET-INDUCED OBESITY; P53 TARGET GENES; INSULIN-RESISTANCE; MUTANT P53; DNA-DAMAGE; GLUCOSE-METABOLISM; LIPID-METABOLISM;

D O I：

10.1016/j.bbcan.2018.06.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

p53 is an important tumour suppressor gene, with loss of p53 contributing to the development of most human cancers. However, the activation of p53 in response to stress signals underpins a role for p53 in diverse aspects of health and disease. Activities of p53 that regulate metabolism can play a role in maintaining homeostasis and protecting cells from damage - so preventing disease development. By contrast, either loss or over-activation of p53 can contribute to numerous metabolic pathologies, including aging, obesity and diabetes.

引用

页码：32 / 42

页数：11

共 166 条

[1] p53 and proliferating cell nuclear antigen (PCNA) expression in non-tumoral liver diseases
Akyol, G
Dursun, A
Poyraz, A
Uluoglu, Ö
Ataoglu, Ö
Edaly, N
Memis, L
[J]. PATHOLOGY INTERNATIONAL, 1999, 49 (03) : 214 - 221
[2] Pharmacological and Genetic Manipulation of p53 in Brown Fat at Adult But Not Embryonic Stages Regulates Thermogenesis and Body Weight in Male Mice
Al-Massadi, Omar
Porteiro, Begona
Kuhlow, Doreen
Koehler, Markus
Gonzalez-Rellan, Maria J.
Garcia-Lavandeira, Montserrat
Diaz-Rodriguez, Esther
Quinones, Mar
Senra, Ana
Alvarez, Clara V.
Lopez, Miguel
Dieguez, Carlos
Schulz, Tim J.
Nogueiras, Ruben
[J]. ENDOCRINOLOGY, 2016, 157 (07) : 2735 - 2749
[3] Requirement of the ATM/p53 Tumor Suppressor Pathway for Glucose Homeostasis
Armata, Heather L.
Golebiowski, Diane
Jung, Dae Young
Ko, Hwi Jin
Kim, Jason K.
Sluss, Hayla K.
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2010, 30 (24) : 5787 - 5794
[4] ROS-Mediated p53 Induction of Lpin1 Regulates Fatty Acid Oxidation in Response to Nutritional Stress
Assaily, Wissam
Rubinger, Daniel A.
Wheaton, Keith
Lin, Yunping
Ma, Weili
Xuan, Wanli
Brown-Endres, Lauren
Tsuchihara, Katsuya
Mak, Tak W.
Benchimol, Samuel
[J]. MOLECULAR CELL, 2011, 44 (03) : 491 - 501
[5] Expression of p53 protein in liver and sera of patients with liver fibrosis, liver cirrhosis or hepatocellular carcinoma associated with chronic HCV infection
Attallah, Abdelfattah M.
Shiha, Gamal E.
Ismail, Hisham
Mansy, Seham E.
EI-Sherbiny, Ranla
El-Dosoky, Ibrahim
[J]. CLINICAL BIOCHEMISTRY, 2009, 42 (06) : 455 - 461
[6] How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression?
Aubrey, Brandon J.
Kelly, Gemma L.
Janic, Ana
Herold, Marco J.
Strasser, Andreas
[J]. CELL DEATH AND DIFFERENTIATION, 2018, 25 (01) : 104 - 113
[7] Aylon Y., 2016, COLD SPRING HARB PER, V6, DOI [10.1101/, DOI 10.1101/]
[8] Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α
Basu, Subhasree
Gnanapradeepan, Keerthana
Barnoud, Thibaut
Kung, Che-Pei
Tavecchio, Michele
Scott, Jeremy
Watters, Andrea
Chen, Qing
Kossenkov, Andrew V.
Murphy, Maureen E.
[J]. GENES & DEVELOPMENT, 2018, 32 (3-4) : 230 - 243
[9] IS P53 POLYMORPHISM MAINTAINED BY NATURAL-SELECTION
BECKMAN, G
BIRGANDER, R
SJALANDER, A
SAHA, N
HOLMBERG, PA
KIVELA, A
BECKMAN, L
[J]. HUMAN HEREDITY, 1994, 44 (05) : 266 - 270
[10] The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes
Belgardt, Bengt-Frederik
Ahmed, Kashan
Spranger, Martina
Latreille, Mathieu
Denzler, Remy
Kondratiuk, Nadiia
von Meyenn, Ferdinand
Villena, Felipe Nunez
Herrmanns, Karolin
Bosco, Domenico
Kerr-Conte, Julie
Pattou, Francois
Ruelicke, Thomas
Stoffel, Markus
[J]. NATURE MEDICINE, 2015, 21 (06) : 619 - 627

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