Control of metabolism by p53-Cancer and beyond

被引：148
作者：
Labuschagne, Christiaan F. [1 ]
Zani, Fabio [1 ]
Vousden, Karen H. [1 ]
机构：
[1] Francis Crick Inst, 1 Midland Rd, London NW1 1AT, England
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2018年 / 1870卷 / 01期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
P53-MEDIATED TUMOR SUPPRESSION; PANCREATIC BETA-CELLS; FATTY-ACID OXIDATION; DIET-INDUCED OBESITY; P53 TARGET GENES; INSULIN-RESISTANCE; MUTANT P53; DNA-DAMAGE; GLUCOSE-METABOLISM; LIPID-METABOLISM;
D O I：
10.1016/j.bbcan.2018.06.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
p53 is an important tumour suppressor gene, with loss of p53 contributing to the development of most human cancers. However, the activation of p53 in response to stress signals underpins a role for p53 in diverse aspects of health and disease. Activities of p53 that regulate metabolism can play a role in maintaining homeostasis and protecting cells from damage - so preventing disease development. By contrast, either loss or over-activation of p53 can contribute to numerous metabolic pathologies, including aging, obesity and diabetes.
引用
收藏
页码：32 / 42
页数：11
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