ILC You Later: Early and Irreparable Loss of Innate Lymphocytes in HIV Infection

被引：3

作者：

Mudd, Joseph C. ^{[1
]}

Brenchley, Jason M. ^{[1
]}

机构：

[1] NIAID, Immunopathogenesis Sect, Mol Microbiol Lab, NIH, Bethesda, MD 20874 USA

来源：

IMMUNITY | 2016年 / 44卷 / 02期

关键词：

LYMPHOID-CELLS;

D O I：

10.1016/j.immuni.2016.01.022

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Loss of IL-17-producing cells in the gut during HIV infection is linked to GI barrier damage. Kloverpris et al. (2016) find that circulating ILCs are lost early and irreversibly during HIV infection. Early ART administration protects against the ILC loss, and this might be clinically beneficial to HIV-infected individuals.

引用

页码：216 / 218

页数：4

共 10 条

[1] The biology of innate lymphoid cells [J].

Artis, David ;

Spits, Hergen .

NATURE, 2015, 517 (7534) :293-301

[2] Microbial translocation, immune activation, and HIV disease [J].

Klatt, Nichole R. ;

Funderburg, Nicholas T. ;

Brenchley, Jason M. .

TRENDS IN MICROBIOLOGY, 2013, 21 (01) :6-13

[3] Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression [J].

Kloverpris, Henrik N. ;

Kazer, Samuel W. ;

Mjosberg, Jenny ;

Mabuka, Jenniffer M. ;

Wellmann, Amanda ;

Ndhlovu, Zaza ;

Yadon, Marisa C. ;

Nhamoyebonde, Shepherd ;

Muenchhoff, Maximilian ;

Simoni, Yannick ;

Andersson, Frank ;

Kuhn, Warren ;

Garrett, Nigel ;

Burgers, Wendy A. ;

Kamya, Philomena ;

Pretorius, Karyn ;

Dong, Krista ;

Moodley, Amber ;

Newell, Evan W. ;

Kasprowicz, Victoria ;

Karim, Salim S. Abdool ;

Goulder, Philip ;

Shalek, Alex K. ;

Walker, Bruce D. ;

Ndung'u, Thumbi ;

Leslie, Alasdair .

IMMUNITY, 2016, 44 (02) :391-405

[4] Residual Immune Dysregulation Syndrome in Treated HIV infection [J].

Lederman, Michael M. ;

Funderburg, Nicholas T. ;

Sekaly, Rafick P. ;

Klatt, Nichole R. ;

Hunt, Peter W. .

ADVANCES IN IMMUNOLOGY, VOL 119, 2013, 119 :51-83

[5] Hypercytotoxicity and Rapid Loss of NKp44+ Innate Lymphoid Cells during Acute SIV Infection [J].

Li, Haiying ;

Richert-Spuhler, Laura E. ;

Evans, Tristan I. ;

Gillis, Jacqueline ;

Connole, Michelle ;

Estes, Jacob D. ;

Keele, Brandon F. ;

Klatt, Nichole R. ;

Reeves, R. Keith .

PLOS PATHOGENS, 2014, 10 (12)

[6]

PANTALEO G, 1993, NEW ENGL J MED, V328, P327, DOI 10.1056/NEJM199302043280508

[7] Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promote cytotoxic potential in NKp44+ mucosal NK cells during SIV infection [J].

Reeves, R. Keith ;

Rajakumar, Premeela A. ;

Evans, Tristan I. ;

Connole, Michelle ;

Gillis, Jacqueline ;

Wong, Fay E. ;

Kuzmichev, Yury V. ;

Carville, Angela ;

Johnson, R. Paul .

BLOOD, 2011, 118 (12) :3321-3330

[8] Transcriptional regulation of innate lymphoid cell fate [J].

Serafini, Nicolas ;

Vosshenrich, Christian A. J. ;

Di Santo, James P. .

NATURE REVIEWS IMMUNOLOGY, 2015, 15 (07) :415-428

[9] IL-17-producing innate lymphoid cells are restricted to mucosal tissues and are depleted in SIV-infected macaques [J].

Xu, H. ;

Wang, X. ;

Liu, D. X. ;

Moroney-Rasmussen, T. ;

Lackner, A. A. ;

Veazey, R. S. .

MUCOSAL IMMUNOLOGY, 2012, 5 (06) :658-669

[10] Plasmacytoid dendritic cells promote HIV-1-induced group 3 innate lymphoid cell depletion [J].

Zhang, Zheng ;

Cheng, Liang ;

Zhao, Juanjuan ;

Li, Guangming ;

Zhang, Liguo ;

Chen, Weiwei ;

Nie, Weiming ;

Reszka-Blanco, Natalia J. ;

Wang, Fu-Sheng ;

Sum, Lishan .

JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (09) :3692-3703

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