MODULATION OF NF-κB IN RESCUED IRRADIATED CELLS

被引：14

作者：

Lam, R. K. K. ^{[1
]}

Fung, Y. K. ^{[1
]}

Han, W. ^{[2
]}

Li, L. ^{[3
]}

Chiu, S. K. ^{[3
]}

Cheng, S. H. ^{[3
,4
]}

Yu, K. N. ^{[1
,2
,4
]}

机构：

[1] City Univ Hong Kong, Dept Phys & Mat Sci, Tat Chee Ave, Hong Kong, Hong Kong, Peoples R China

[2] Chinese Acad Sci, Hefei Inst Phys Sci, Ctr Med Phys & Technol, Hefei 230031, Peoples R China

[3] City Univ Hong Kong, Dept Biomed Sci, Tat Chee Ave, Hong Kong, Hong Kong, Peoples R China

[4] City Univ Hong Kong, State Key Lab Marine Pollut, Tat Chee Ave, Hong Kong, Hong Kong, Peoples R China

来源：

RADIATION PROTECTION DOSIMETRY | 2015年 / 167卷 / 1-3期

关键词：

DOUBLE-STRAND BREAKS; NECROSIS-FACTOR-ALPHA; DNA-DAMAGE; IONIZING-RADIATION; NITRIC-OXIDE; BYSTANDER RESPONSE; FUTURE-DIRECTIONS; HUMAN FIBROBLASTS; IN-VIVO; CANCER;

D O I：

10.1093/rpd/ncv217

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Studies by different groups on the rescue effect, where unirradiated bystander cells mitigated the damages in the irradiated cells, since its discovery by the authors' group in 2011 were first reviewed. The properties of the rescue effect were then examined using a novel experimental set-up to physically separate the rescue signals from the bystander signals. The authors' results showed that the rescue effect was mediated through activation of the nuclear factor-kappa B (NF-kappa B) response pathway in the irradiated cells, and that the NF-kappa B activation inhibitor BAY-11-7082 did not affect the activation of this response pathway in the irradiated cells induced by direct irradiation.

引用

页码：37 / 43

页数：7

共 43 条

[1] Checkpoint signalling: focusing on 53BP1 [J].

Abraham, RT .

NATURE CELL BIOLOGY, 2002, 4 (12) :E277-E279

[2] Tumor necrosis factor receptor-associated factors (TRAFs) - a family of adaptor proteins that regulates life and death [J].

Arch, RH ;

Gedrich, RW ;

Thompson, CB .

GENES & DEVELOPMENT, 1998, 12 (18) :2821-2830

[3] Rescue effects in radiobiology: Unirradiated bystander cells assist irradiated cells through intercellular signal feedback [J].

Chen, S. ;

Zhao, Y. ;

Han, W. ;

Chiu, S. K. ;

Zhu, L. ;

Wu, L. ;

Yu, K. N. .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2011, 706 (1-2) :59-64

[4] α-Particle Irradiated Zebrafish Embryos Rescued by Bystander Unirradiated Zebrafish Embryos [J].

Choi, V. W. Y. ;

Ng, C. Y. P. ;

Cheng, S. H. ;

Yu, K. N. .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2012, 46 (01) :226-231

[5] Radiation-induced hepatitis B virus reactivation in liver mediated by the bystander effect from irradiated endothelial cells [J].

Chou, Chia Hung ;

Chen, Pei-Jer ;

Lee, Po-Huang ;

Cheng, Ann-Lii ;

Hsu, Hui-Chen ;

Cheng, Andjason Chia-Hsien .

CLINICAL CANCER RESEARCH, 2007, 13 (03) :851-857

[6] Damaging and protective bystander cross-talk between human lung cancer and normal cells after proton microbeam irradiation [J].

Desai, Sejal ;

Kobayashi, Alisa ;

Konishi, Teruaki ;

Oikawa, Masakazu ;

Pandey, Badri N. .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2014, 763 :39-44

[7] IAP family proteins - suppressors of apoptosis [J].

Deveraux, QL ;

Reed, TC .

GENES & DEVELOPMENT, 1999, 13 (03) :239-252

[8] Retention but not recruitment of Crb2 at double-strand breaks requires Rad1 and Rad3 complexes [J].

Du, LL ;

Nakamura, TM ;

Moser, BA ;

Russell, P .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (17) :6150-6158

[9] Gamma ray-induced bystander effect in tumour glioblastoma cells: A specific study on cell survival, cytokine release and cytokine receptors [J].

Facoetti, A. ;

Ballarini, F. ;

Cherubini, R. ;

Gerardi, S. ;

Nano, R. ;

Ottolenghi, A. ;

Prise, K. M. ;

Trott, K. R. ;

Zilio, C. .

RADIATION PROTECTION DOSIMETRY, 2006, 122 (1-4) :271-274

[10]

Goldberg Z, 2002, INT J ONCOL, V21, P337

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