Pathogenesis of thoracic and abdominal aortic aneurysms

被引:190
作者
Guo, Dong-Chuan
Papke, Christina L.
He, Rumin
Milewicz, Dianna M.
机构
[1] Univ Texas, Sch Med, Dept Internal Med, Houston, TX 77030 USA
[2] Shanghai Jiao Tong Univ, Ruijin Hosp, Coll Med, Shanghai, Peoples R China
来源
ABDOMINAL AORTIC ANEURYSM: GENETICS, PATHOPHYSIOLOGY AND MOLECULAR BIOLOGY | 2006年 / 1085卷
关键词
abdominal aortic aneurysm; thoracic aortic aneurysm; apoptosis; inflammation; pathogenesis;
D O I
10.1196/annals.1383.013
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The major disease processes affecting the aorta are aortic aneurysms and dissections. Aneurysms are usually described in terms of their anatomic location, with thoracic aortic aneurysms (TAAs) involving the ascending and descending aorta in the thoracic cavity and abdominal aortic aneurysms (AAAs) involving the infrarenal abdominal aorta. Both thoracic and abdominal aortas are elastic arteries, and share similarities in their physical structures and cellular components. However, thoracic and abdominal aortas differ in their biochemical properties and the origin of their vascular smooth muscle cells (VSMCs). These similarities and differences between thoracic and abdominal aortas provide the basis for the various pathologic mechanisms observed in this disease. This review focuses on the comparison of the pathologic mechanisms involved in TAA and AAA.
引用
收藏
页码:339 / 352
页数:14
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