Bioactive metabolites from the Caribbean sponge Aka coralliphagum

被引：47
作者：
Grube, Achim
Assmann, Michael
Lichte, Ellen
Sasse, Florenz
Pawlik, Joseph R.
Koeck, Matthias
机构：
[1] Alfred Wegener Inst Polar & Meeresforsch Helmholt, D-27570 Bremerhaven, Germany
[2] Helmholtz Ctr Infect Res, D-38124 Braunschweig, Germany
[3] Univ N Carolina, Ctr Marine Sci, Wilmington, NC 28409 USA
来源：
JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 04期
关键词：
D O I：
10.1021/np0603018
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The chemistry of the burrowing sponge Aka coralliphagum was investigated to identify chemically labile secondary metabolites. The HPLC-MS analysis of the two growth forms typica and incrustans revealed different metabolites. The previously unknown sulfated compounds siphonodictyals B1 to B3 (6-8), corallidictyals C (9) and D (10), and siphonodictyal G (11) were isolated, and their structures were elucidated by NMR and MS experiments. The compounds were tested in a DPPH assay, in antimicrobial assays against bacteria, yeasts, and fungi, and in antiproliferation assays using cultures of mouse fibroblasts. The biological activity was linked to the presence of the ortho-hydroquinone moiety.
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页码：504 / 509
页数：6
相关论文
共 18 条
  • [1] Sigmosceptrins A-C: New norditerpenes from a southern Australian marine sponge, Sigmosceptrella sp.
    Bassett, S
    Ovenden, SPB
    Gable, RW
    Capon, RJ
    [J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1997, 50 (12) : 1137 - 1143
  • [2] A new approach to sesquiterpene arenes of the 9,11-drimenyl type (=[(1E,2RS,4aRS,8aRS)-octahydro-2,5,5,8a-tetramethylnaphthalen-1(2H)-ylidene] methyl type)
    Bernet, A
    Seifert, K
    [J]. HELVETICA CHIMICA ACTA, 2006, 89 (04) : 784 - 796
  • [3] PROTEIN-KINASE-C INHIBITORS - NOVEL SPIROSESQUITERPENE ALDEHYDES FROM A MARINE SPONGE AKA (=SIPHONODICTYON) CORALLIPHAGUM
    CHAN, JA
    FREYER, AJ
    CARTE, BK
    HEMLING, ME
    HOFMANN, GA
    MATTERN, MR
    MENTZER, MA
    WESTLEY, JW
    [J]. JOURNAL OF NATURAL PRODUCTS-LLOYDIA, 1994, 57 (11): : 1543 - 1548
  • [4] STRUCTURAL STUDY OF (-)-8-EPI-11-NORDRIMAN-9-ONE
    DASTLIK, KA
    GHISALBERTI, EL
    SKELTON, BW
    WHITE, AH
    [J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1991, 44 (01) : 123 - 127
  • [5] SOME METABOLITES OF THE MARINE SPONGES SMENOSPONGIA-AUREA AND SMENOSPONGIA (=POLYFIBROSPONGIA) ECHINA
    DJURA, P
    STIERLE, DB
    SULLIVAN, B
    FAULKNER, DJ
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1980, 45 (08) : 1435 - 1441
  • [6] Antioxidative meroterpenoids from the brown alga Cystoseira crinita
    Fisch, KM
    Böhm, V
    Wright, AD
    König, GM
    [J]. JOURNAL OF NATURAL PRODUCTS, 2003, 66 (07): : 968 - 975
  • [7] Kang HS, 2003, CHEM PHARM BULL, V51, P1012, DOI 10.1248/cpb.51.1012
  • [8] NEW QUINONES FROM A DICTYOCERATID SPONGE
    KAZLAUSKAS, R
    MURPHY, PT
    WARREN, RG
    WELLS, RJ
    BLOUNT, JF
    [J]. AUSTRALIAN JOURNAL OF CHEMISTRY, 1978, 31 (12) : 2685 - 2697
  • [9] IDENTIFICATION AND QUANTIFICATION OF LIPID SULFATE ESTERS BY ELECTROSPRAY-IONIZATION MS/MS TECHNIQUES - CHOLESTEROL SULFATE
    METZGER, K
    REHBERGER, PA
    ERBEN, G
    LEHMANN, WD
    [J]. ANALYTICAL CHEMISTRY, 1995, 67 (22) : 4178 - 4183
  • [10] The molecular mechanism of bee venom phospholipase A2 inactivation by bolinaquinone
    Monti, Maria Chiara
    Casapullo, Agostino
    Santomauro, Cosima
    D'Auria, Maria Valeria
    Riccio, Raffaele
    Gomez-Paloma, Luigi
    [J]. CHEMBIOCHEM, 2006, 7 (06) : 971 - 980
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