Gadolinium deposition within the dentate nucleus and globus pallidus after repeated administrations of gadolinium-based contrast agents-current status

被引:98
作者
Stojanov, Dragan [1 ,2 ]
Aracki-Trenkic, Aleksandra [2 ]
Benedeto-Stojanov, Daniela [1 ]
机构
[1] Univ Nis, Fac Med, Bul Dr Zorana Djindjica 81, Nish 18000, Serbia
[2] Clin Ctr Nis, Ctr Radiol, Nish, Serbia
关键词
Magnetic resonance imaging; Gadolinium deposition; Contrast media; Globus pallidus; Dentate nucleus; T1-WEIGHTED MR-IMAGES; NEPHROGENIC SYSTEMIC FIBROSIS; HIGH-SIGNAL INTENSITY; ACUTE ADVERSE-REACTIONS; HYPERINTENSE BASAL GANGLIA; PLASMA-MASS SPECTROSCOPY; HEALTHY RATS DIFFERENCE; DEEP CEREBELLAR NUCLEI; MULTIPLE-SCLEROSIS; GADOPENTETATE DIMEGLUMINE;
D O I
10.1007/s00234-016-1658-1
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Introduction Gadolinium-based contrast agents (GBCAs) have been used clinically since 1988 for contrast-enhanced magnetic resonance imaging (CE-MRI). Generally, GBCAs are considered to have an excellent safety profile. However, GBCA administration has been associated with increased occurrence of nephrogenic systemic fibrosis (NSF) in patients with severely compromised renal function, and several studies have shown evidence of gadolinium deposition in specific brain structures, the globus pallidus and dentate nucleus, in patients with normal renal function. Methods Gadolinium deposition in the brain following repeated CE-MRI scans has been demonstrated in patients using T1-weighted unenhanced MRI and inductively coupled plasma mass spectroscopy. Additionally, rodent studies with controlled GBCA administration also resulted in neural gadolinium deposits. Results Repeated GBCA use is associated with gadolinium deposition in the brain. This is especially true with the use of less-stable, linear GBCAs. In spite of increasing evidence of gadolinium deposits in the brains of patients after multiple GBCA administrations, the clinical significance of these deposits continues to be unclear. Conclusion Here, we discuss the current state of scientific evidence surrounding gadolinium deposition in the brain following GBCA use, and the potential clinical significance of gadolinium deposition. There is considerable need for further research, both to understand the mechanism by which gadolinium deposition in the brain occurs and how it affects the patients in which it occurs.
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页码:433 / 441
页数:9
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