[3] Leiden Univ Med Ctr, Dept Radiol, Div Image Proc, NL-2333ZC Leiden, Netherlands
[4] Leiden Univ Med Ctr, Dept Human Genet, NL-2333ZC Leiden, Netherlands
来源:
BIOINFORMATICS ADVANCES
|
2022年
/
2卷
/
01期
基金:
欧盟地平线“2020”;
关键词:
D O I:
10.1093/bioadv/vbac011
中图分类号:
Q [生物科学];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
Motivation Single-cell multi-omics assays simultaneously measure different molecular features from the same cell. A key question is how to benefit from the complementary data available and perform cross-modal clustering of cells.Results We propose Single-Cell Multi-omics Clustering (scMoC), an approach to identify cell clusters from data with comeasurements of scRNA-seq and scATAC-seq from the same cell. We overcome the high sparsity of the scATAC-seq data by using an imputation strategy that exploits the less-sparse scRNA-seq data available from the same cell. Subsequently, scMoC identifies clusters of cells by merging clusterings derived from both data domains individually. We tested scMoC on datasets generated using different protocols with variable data sparsity levels. We show that scMoC (i) is able to generate informative scATAC-seq data due to its RNA-guided imputation strategy and (ii) results in integrated clusters based on both RNA and ATAC information that are biologically meaningful either from the RNA or from the ATAC perspective.Availability and implementation The data used in this manuscript is publicly available, and we refer to the original manuscript for their description and availability. For convience sci-CAR data is available at NCBI GEO under the accession number of GSE117089. SNARE-seq data is available at NCBI GEO under the accession number of GSE126074. The 10X multiome data is available at the following link https://www.10xgenomics.com/resources/datasets/pbmc-from-a-healthy-donor-no-cell-sorting-3-k-1-standard-2-0-0.Supplementary information are available at Bioinformatics Advances online.
机构:
Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 03722, South KoreaYonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 03722, South Korea
Baek, Seungbyn
Lee, Insuk
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 03722, South Korea
Yonsei Univ, Dept Biomed Syst Informat, Coll Med, Seoul 03722, South KoreaYonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 03722, South Korea
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
Univ Washington, Mol & Cellular Biol Program, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Cao, Junyue
Cusanovich, Darren A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
Univ Arizona, Asthma & Airway Dis Res Ctr, Tucson, AZ USA
Univ Arizona, Dept Cellular & Mol Med, Tucson, AZ USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Cusanovich, Darren A.
Ramani, Vijay
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Ramani, Vijay
Aghamirzaie, Delasa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Aghamirzaie, Delasa
论文数: 引用数:
h-index:
机构:
Pliner, Hannah A.
Hill, Andrew J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Hill, Andrew J.
Daza, Riza M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Daza, Riza M.
McFaline-Figueroa, Jose L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
McFaline-Figueroa, Jose L.
Packer, Jonathan S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Packer, Jonathan S.
Christiansen, Lena
论文数: 0引用数: 0
h-index: 0
机构:
Illumina Inc, San Diego, CA USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Christiansen, Lena
Steemers, Frank J.
论文数: 0引用数: 0
h-index: 0
机构:
Illumina Inc, San Diego, CA USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Steemers, Frank J.
Adey, Andrew C.
论文数: 0引用数: 0
h-index: 0
机构:
Oregon Hlth & Sci Univ, Dept Mol & Med Genet, Portland, OR 97201 USA
Knight Cardiovasc Inst, Portland, OR USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Adey, Andrew C.
论文数: 引用数:
h-index:
机构:
Trapnell, Cole
Shendure, Jay
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
Allen Discovery Ctr Cell Lineage Tracing, Seattle, WA 98195 USA
Brotman Baty Inst Precis Med, Seattle, WA 98195 USA
Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
机构:
Massachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA 02129 USA
Harvard Med Sch, Dept Pathol, Boston, MA 02115 USA
Broad Inst Harvard & MIT, Cambridge, MA 02142 USAMassachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Chen, Huidong
Lareau, Caleb A.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Broad Inst Harvard & MIT, Cambridge, MA 02142 USA
Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USAMassachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Lareau, Caleb A.
Andreani, Tommaso
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA 02129 USA
Harvard Med Sch, Dept Pathol, Boston, MA 02115 USA
Johannes Gutenberg Univ Mainz, Fac Biol, Computat Biol & Data Min Lab, D-55128 Mainz, GermanyMassachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Andreani, Tommaso
Vinyard, Michael E.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA 02129 USA
Harvard Med Sch, Dept Pathol, Boston, MA 02115 USA
Broad Inst Harvard & MIT, Cambridge, MA 02142 USA
Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02142 USAMassachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Vinyard, Michael E.
Garcia, Sara P.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USAMassachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Garcia, Sara P.
Clement, Kendell
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA 02129 USA
Harvard Med Sch, Dept Pathol, Boston, MA 02115 USA
Broad Inst Harvard & MIT, Cambridge, MA 02142 USAMassachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Clement, Kendell
Andrade-Navarro, Miguel
论文数: 0引用数: 0
h-index: 0
机构:
Johannes Gutenberg Univ Mainz, Fac Biol, Computat Biol & Data Min Lab, D-55128 Mainz, GermanyMassachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Andrade-Navarro, Miguel
Buenrostro, Jason D.
论文数: 0引用数: 0
h-index: 0
机构:
Broad Inst Harvard & MIT, Cambridge, MA 02142 USA
Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USAMassachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Buenrostro, Jason D.
Pinello, Luca
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA 02129 USA
Harvard Med Sch, Dept Pathol, Boston, MA 02115 USA
Broad Inst Harvard & MIT, Cambridge, MA 02142 USAMassachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Cusanovich, Darren A.
Reddington, James P.
论文数: 0引用数: 0
h-index: 0
机构:
EMBL, Genome Biol Unit, Heidelberg, GermanyUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Reddington, James P.
Garfield, David A.
论文数: 0引用数: 0
h-index: 0
机构:
EMBL, Genome Biol Unit, Heidelberg, Germany
Humboldt Univ, IRI Life Sci, Berlin, GermanyUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Garfield, David A.
Daza, Riza M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Daza, Riza M.
Aghamirzaie, Delasa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Aghamirzaie, Delasa
Marco-Ferreres, Raquel
论文数: 0引用数: 0
h-index: 0
机构:
EMBL, Genome Biol Unit, Heidelberg, GermanyUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Marco-Ferreres, Raquel
论文数: 引用数:
h-index:
机构:
Pliner, Hannah A.
Christiansen, Lena
论文数: 0引用数: 0
h-index: 0
机构:
Illumina, San Diego, CA USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Christiansen, Lena
Qiu, Xiaojie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Qiu, Xiaojie
Steemers, Frank J.
论文数: 0引用数: 0
h-index: 0
机构:
Illumina, San Diego, CA USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Steemers, Frank J.
论文数: 引用数:
h-index:
机构:
Trapnell, Cole
Shendure, Jay
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
Howard Hughes Med Inst, Seattle, WA USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Shendure, Jay
Furlong, Eileen E. M.
论文数: 0引用数: 0
h-index: 0
机构:
EMBL, Genome Biol Unit, Heidelberg, GermanyUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
机构:
Ohio State Univ, Dept Biomed Informat, Columbus, OH 43235 USAOhio State Univ, Dept Biomed Informat, Columbus, OH 43235 USA
Ma, Anjun
论文数: 引用数:
h-index:
机构:
McDermaid, Adam
Xu, Jennifer
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Biomed Informat, Columbus, OH 43235 USA
Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USAOhio State Univ, Dept Biomed Informat, Columbus, OH 43235 USA
Xu, Jennifer
Chang, Yuzhou
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Biomed Informat, Columbus, OH 43235 USAOhio State Univ, Dept Biomed Informat, Columbus, OH 43235 USA
Chang, Yuzhou
Ma, Qin
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Biomed Informat, Columbus, OH 43235 USAOhio State Univ, Dept Biomed Informat, Columbus, OH 43235 USA
机构:
Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 03722, South KoreaYonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 03722, South Korea
Baek, Seungbyn
Lee, Insuk
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 03722, South Korea
Yonsei Univ, Dept Biomed Syst Informat, Coll Med, Seoul 03722, South KoreaYonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 03722, South Korea
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
Univ Washington, Mol & Cellular Biol Program, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Cao, Junyue
Cusanovich, Darren A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
Univ Arizona, Asthma & Airway Dis Res Ctr, Tucson, AZ USA
Univ Arizona, Dept Cellular & Mol Med, Tucson, AZ USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Cusanovich, Darren A.
Ramani, Vijay
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Ramani, Vijay
Aghamirzaie, Delasa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Aghamirzaie, Delasa
论文数: 引用数:
h-index:
机构:
Pliner, Hannah A.
Hill, Andrew J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Hill, Andrew J.
Daza, Riza M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Daza, Riza M.
McFaline-Figueroa, Jose L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
McFaline-Figueroa, Jose L.
Packer, Jonathan S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Packer, Jonathan S.
Christiansen, Lena
论文数: 0引用数: 0
h-index: 0
机构:
Illumina Inc, San Diego, CA USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Christiansen, Lena
Steemers, Frank J.
论文数: 0引用数: 0
h-index: 0
机构:
Illumina Inc, San Diego, CA USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Steemers, Frank J.
Adey, Andrew C.
论文数: 0引用数: 0
h-index: 0
机构:
Oregon Hlth & Sci Univ, Dept Mol & Med Genet, Portland, OR 97201 USA
Knight Cardiovasc Inst, Portland, OR USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Adey, Andrew C.
论文数: 引用数:
h-index:
机构:
Trapnell, Cole
Shendure, Jay
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
Allen Discovery Ctr Cell Lineage Tracing, Seattle, WA 98195 USA
Brotman Baty Inst Precis Med, Seattle, WA 98195 USA
Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
机构:
Massachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA 02129 USA
Harvard Med Sch, Dept Pathol, Boston, MA 02115 USA
Broad Inst Harvard & MIT, Cambridge, MA 02142 USAMassachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Chen, Huidong
Lareau, Caleb A.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Broad Inst Harvard & MIT, Cambridge, MA 02142 USA
Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USAMassachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Lareau, Caleb A.
Andreani, Tommaso
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA 02129 USA
Harvard Med Sch, Dept Pathol, Boston, MA 02115 USA
Johannes Gutenberg Univ Mainz, Fac Biol, Computat Biol & Data Min Lab, D-55128 Mainz, GermanyMassachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Andreani, Tommaso
Vinyard, Michael E.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA 02129 USA
Harvard Med Sch, Dept Pathol, Boston, MA 02115 USA
Broad Inst Harvard & MIT, Cambridge, MA 02142 USA
Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02142 USAMassachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Vinyard, Michael E.
Garcia, Sara P.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USAMassachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Garcia, Sara P.
Clement, Kendell
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA 02129 USA
Harvard Med Sch, Dept Pathol, Boston, MA 02115 USA
Broad Inst Harvard & MIT, Cambridge, MA 02142 USAMassachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Clement, Kendell
Andrade-Navarro, Miguel
论文数: 0引用数: 0
h-index: 0
机构:
Johannes Gutenberg Univ Mainz, Fac Biol, Computat Biol & Data Min Lab, D-55128 Mainz, GermanyMassachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Andrade-Navarro, Miguel
Buenrostro, Jason D.
论文数: 0引用数: 0
h-index: 0
机构:
Broad Inst Harvard & MIT, Cambridge, MA 02142 USA
Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USAMassachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Buenrostro, Jason D.
Pinello, Luca
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
Massachusetts Gen Hosp, Ctr Canc Res, Charlestown, MA 02129 USA
Harvard Med Sch, Dept Pathol, Boston, MA 02115 USA
Broad Inst Harvard & MIT, Cambridge, MA 02142 USAMassachusetts Gen Hosp, Res Inst, Mol Pathol Unit, Charlestown, MA 02129 USA
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Cusanovich, Darren A.
Reddington, James P.
论文数: 0引用数: 0
h-index: 0
机构:
EMBL, Genome Biol Unit, Heidelberg, GermanyUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Reddington, James P.
Garfield, David A.
论文数: 0引用数: 0
h-index: 0
机构:
EMBL, Genome Biol Unit, Heidelberg, Germany
Humboldt Univ, IRI Life Sci, Berlin, GermanyUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Garfield, David A.
Daza, Riza M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Daza, Riza M.
Aghamirzaie, Delasa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Aghamirzaie, Delasa
Marco-Ferreres, Raquel
论文数: 0引用数: 0
h-index: 0
机构:
EMBL, Genome Biol Unit, Heidelberg, GermanyUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Marco-Ferreres, Raquel
论文数: 引用数:
h-index:
机构:
Pliner, Hannah A.
Christiansen, Lena
论文数: 0引用数: 0
h-index: 0
机构:
Illumina, San Diego, CA USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Christiansen, Lena
Qiu, Xiaojie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Qiu, Xiaojie
Steemers, Frank J.
论文数: 0引用数: 0
h-index: 0
机构:
Illumina, San Diego, CA USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Steemers, Frank J.
论文数: 引用数:
h-index:
机构:
Trapnell, Cole
Shendure, Jay
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA
Howard Hughes Med Inst, Seattle, WA USAUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
Shendure, Jay
Furlong, Eileen E. M.
论文数: 0引用数: 0
h-index: 0
机构:
EMBL, Genome Biol Unit, Heidelberg, GermanyUniv Washington, Dept Genome Sci, Seattle, WA 98195 USA
机构:
Ohio State Univ, Dept Biomed Informat, Columbus, OH 43235 USAOhio State Univ, Dept Biomed Informat, Columbus, OH 43235 USA
Ma, Anjun
论文数: 引用数:
h-index:
机构:
McDermaid, Adam
Xu, Jennifer
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Biomed Informat, Columbus, OH 43235 USA
Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USAOhio State Univ, Dept Biomed Informat, Columbus, OH 43235 USA
Xu, Jennifer
Chang, Yuzhou
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Biomed Informat, Columbus, OH 43235 USAOhio State Univ, Dept Biomed Informat, Columbus, OH 43235 USA
Chang, Yuzhou
Ma, Qin
论文数: 0引用数: 0
h-index: 0
机构:
Ohio State Univ, Dept Biomed Informat, Columbus, OH 43235 USAOhio State Univ, Dept Biomed Informat, Columbus, OH 43235 USA