Selective hippocampal subfield volume reductions in World Trade Center responders with cognitive impairment

被引：8

作者：

Deri, Yael ^{[1
]}

Clouston, Sean A. P. ^{[2
,3
]}

DeLorenzo, Christine ^{[4
,5
]}

Gardus, John D., III ^{[4
]}

Horton, Megan ^{[6
]}

Tang, Cheuk ^{[7
]}

Pellecchia, Alison C. ^{[10
]}

Santiago-Michels, Stephanie ^{[10
]}

Carr, Melissa A. ^{[10
]}

Gandy, Sam ^{[8
,9
,11
]}

Sano, Mary ^{[11
]}

Bromet, Evelyn J. ^{[4
]}

Lucchini, Roberto G. ^{[6
]}

Luft, Benjamin J. ^{[1
,10
]}

机构：

[1] SUNY Stony Brook, Renaissance Sch Med, Dept Med, Stony Brook, NY 11794 USA

[2] SUNY Stony Brook, Renaissance Sch Med, Program Publ Hlth, Stony Brook, NY 11794 USA

[3] SUNY Stony Brook, Renaissance Sch Med, Dept Family Populat & Prevent Med, Stony Brook, NY 11794 USA

[4] SUNY Stony Brook, Renaissance Sch Med, Dept Psychiat, Stony Brook, NY 11794 USA

[5] SUNY Stony Brook, Dept Biomed Engn, Stony Brook, NY 11794 USA

[6] Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA

[7] Icahn Sch Med Mt Sinai, Biomed Engn & Imaging Inst, New York, NY 10029 USA

[8] Icahn Sch Med Mt Sinai, Barbara & Maurice Deane Ctr Wellness & Cognit Hlt, New York, NY 10029 USA

[9] Icahn Sch Med Mt Sinai, Mt Sinai Ctr NFL Neurol Care, Dept Neurol, New York, NY 10029 USA

[10] SUNY Stony Brook, Stony Brook World Trade Ctr Wellness Program, Renaissance Sch Med, Stony Brook, NY 11794 USA

[11] Icahn Sch Med Mt Sinai, Mt Sinai Alzheimers Dis Res Ctr, New York, NY 10029 USA

来源：

ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING | 2021年 / 13卷 / 01期

关键词：

cognitive impairment; hippocampal subfields; post‐ traumatic stress disorder; World Trade Center responder; POSTTRAUMATIC-STRESS-DISORDER; FINE PARTICULATE MATTER; COGSTATE BRIEF BATTERY; ALZHEIMERS-DISEASE; WHOLE-BRAIN; DEMENTIA; SEGMENTATION; HEALTH; CONSEQUENCES; ASSOCIATION;

D O I：

10.1002/dad2.12165

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction The objective of this study was to investigate associations between dementia in World Trade Center (WTC) responders and in vivo volumetric measures of hippocampal subfield volumes in WTC responders at midlife. Methods A sample of 99 WTC responders was divided into dementia and unimpaired groups. Participants underwent structural T1-weighted magnetic resonance imaging. Volumetric measures included the overall hippocampus and eight subfields. Regression models examined volumetric measure of interest adjusting for confounders including intracranial volume. Results Dementia was associated with smaller hippocampal volume and with reductions across hippocampal subfields. Smaller hippocampal subfield volumes were associated with longer cumulative time worked at the WTC. Domain-specific cognitive performance was associated with lower volumetric measures across hippocampal subregions. Conclusions This is the first study to investigate hippocampal subfield volumes in a sample of WTC responders at midlife. Selective hippocampal subfield volume reductions suggested abnormal cognition that were associated with WTC exposure duration.

引用

页数：12

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