Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography

被引：45

作者：

Quarto, Giovanna ^{[1
]}

Spinelli, Lorenzo ^{[2
]}

Pifferi, Antonio ^{[1
,2
]}

Torricelli, Alessandro ^{[1
]}

Cubeddu, Rinaldo ^{[1
,2
]}

Abbate, Francesca ^{[3
]}

Balestreri, Nicola ^{[4
]}

Menna, Simona ^{[3
]}

Cassano, Enrico ^{[3
]}

Taroni, Paola ^{[1
,2
]}

机构：

[1] Politecn Milan, Dipartimento Fis, I-20133 Milan, Italy

[2] CNR, Ist Foton & Nanotecnol, I-20133 Milan, Italy

[3] European Inst Oncol, Breast Imaging Unit, I-20141 Milan, Italy

[4] European Inst Oncol, Dept Radiol, I-20141 Milan, Italy

来源：

BIOMEDICAL OPTICS EXPRESS | 2014年 / 5卷 / 10期

关键词：

NEAR-INFRARED TOMOGRAPHY; IN-VIVO; OXYGEN-SATURATION; DIFFUSION EQUATION; CANCER DETECTION; HEMOGLOBIN; SCATTERING; TUMORS; QUANTIFICATION; SPECTROSCOPY;

D O I：

10.1364/BOE.5.003684

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The optical characterization of malignant and benign breast lesions is presented. Time-resolved transmittance measurements were performed in the 630-1060 nm range by means of a 7-wavelength optical mammograph, providing both imaging and spectroscopy information. A total of 62 lesions were analyzed, including 33 malignant and 29 benign lesions. The characterization of breast lesions was performed applying a perturbation model based on the high-order calculation of the pathlength of photons inside the lesion, which led to the assessment of oxy- and deoxy-hemoglobin, lipids, water and collagen concentrations. Significant variations between tumor and healthy tissue were observed in terms of both absorption properties and constituents concentration. In particular, benign lesions and tumors show a statistically significant discrimination in terms of absorption at several wavelengths and also in terms of oxy-hemoglobin and collagen content. (C) 2014 Optical Society of America

引用

页码：3684 / 3698

页数：15

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