Barbaram, a bicyclic neolactam from the root and stem of Lycium barbarum

被引：4

作者：

Lan, Ting ^{[1
]}

Xu, Wei ^{[1
]}

Xu, Tian-Qi ^{[1
]}

Xia, Zhao ^{[1
]}

Zhang, Hai-Xin ^{[1
]}

Zhan, Ya-Ping ^{[1
]}

Zhou, Guang-Xiong ^{[1
]}

机构：

[1] Jinan Univ, Guangdong Prov Key Lab Pharmacodynam Constituents, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2021年 / 23卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Lycium barbarum; Solanaceae; root and stem; neolactam; ECD calculations; anti-inflammatory activity; GENUS LYCIUM; MEDICINE;

D O I：

10.1080/10286020.2019.1706498

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Barbaram (1), a neolactam together with other five known compunds (2-6) was isolated from the EtOAc-soluble fraction of an EtOH extract of the root and stem of Lycium barbarum by using silica gel, Sephadex LH-20 column chromatography and semi-preparative RP-C-18 HPLC. Based on HR-TOF-MS, NMR spectral data, quantum chemistry ECD calculations and referencing to the data reported earlier, the structures of these compounds (1-6) were determined, specially including the absolute configuration of the neolactam (1). Compounds 2 and 4 showed significant anti-inflammatory activity in LPS-induced RAW 264.7 macrophages with the IC50 values of 8.98 +/- 0.57 mu M, 6.68 +/- 0.77 mu M.

引用

页码：82 / 88

页数：7

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