Gorgan (Turkmen in Iran) HLA genetics: transplantation, pharmacogenomics and anthropology

被引：7
作者：
Rey, Diego [1 ]
Amirzargar, Ali [2 ]
Areces, Cristina [1 ]
Enriquez-de-Salamanca, Mercedes [1 ]
Marco, Javier [1 ]
Abd-El-Fatah-Khalil, Sedeka [3 ]
Fernandez-Honrado, Mercedes [3 ]
Muniz, Ester [1 ]
Manuel Martin-Villa, Jose [1 ]
Arnaiz-Villena, Antonio [1 ]
机构：
[1] Univ Complutense, Dept Immunol, Sch Med, Madrid Reg Blood Ctr, E-28040 Madrid, Spain
[2] Univ Tehran Med Sci, Sch Med, Mol Immunol Res Ctr, Tehran, Iran
[3] Madrid Reg Blood Ctr, Dept Haematol, Madrid, Spain
来源：
IMMUNOLOGICAL INVESTIGATIONS | 2015年 / 44卷 / 01期
关键词：
Anthropology; Asian; Gorgan; HLA; Iran; Kurgan; Mediterranean; pharmacogenomics; Turkmen; MEDITERRANEAN POPULATIONS; SIBERIAN POPULATIONS; PHYLOGENETIC TREES; ALLELE FREQUENCIES; MOLECULAR ANALYSIS; ASHKENAZI JEWS; POLYMORPHISM; GENES; ORIGIN; MOROCCAN;
D O I：
10.3109/08820139.2014.936938
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
HLA class I and II alleles have been studied in a population from Gorgan (North East Iranian city bordering Turkmenistan). This population is composed of mainly Turkmen who speak Oghuz Turkish language. Comparison of Gorgan people HLA profile has been carried out with about 7984 HLA chromosomes from other worldwide populations; extended haplotypes and three dimension genetic distances have been calculated by using neighbor-joining and correspondence relatedness analyses. Most frequent extended HLA haplotypes show a Siberian/Mediterranean admixture and closest populations are Chuvashians (North Caspian Sea, Russia) and other geographically close populations like Siberian Mansi, Buryats and other Iranians. New extended HLA haplotypes have been found, such as: A*31:01-B*35:01-DRB1*15:01-DQB1*03:01, A*01:01-B*35:01-DRB1*03:01-DQB1*02:01. Relationships of Turkmen with Kurgan (Gorgan) archaeological mounds, Scythians and Sarmatians are discussed. This study is also useful for a future transplantation Gorgan waiting list, Gorgan HLA and disease epidemiology and HLA pharmacogenomics.
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页码：88 / 100
页数：13
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