Synthesis, and characterization folate-conjugated photocleavable poly(4-substituted-ε-caprolactone) polymers for drug delivery

被引：1

作者：

Fang, Jia-You ^{[1
]}

Lin, Yin-Ku ^{[2
]}

Wang, Shiu-Wei ^{[3
]}

Lee, Ren-Shen ^{[3
]}

机构：

[1] Chang Gung Univ, Grad Inst Nat Prod, Taoyuan, Taiwan

[2] Chang Gung Mem Hosp, Dept Tradit Chinese Med, Keelung, Taiwan

[3] Chang Gung Univ, Div Nat Sci, Ctr Gen Educ, 259 Wen Hwa 1st Rd, Taoyuan 33302, Taiwan

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2020年 / 69卷 / 01期

关键词：

Photo-cleavable; folic acid; micellization; polyester; target; BLOCK-COPOLYMERS; NANOPARTICLES; MICELLES; PH; RELEASE; DESIGN;

D O I：

10.1080/00914037.2018.1539987

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Photo-cleavable polymers containing 5-hydroxy-2-nitrobenzyl alcohol (ONB) junction point between the target molecule of folic acid (FA) and the hydrophobic poly(4-substituted--caprolactone) (PXCLn) chain were synthesized. FA -terminated ONB-PXCLn polymers formed micelles with critical micelle concentration (CMC) 1.2 - 64.3mg L-1. Fluorescence emission spectroscopy indicated the release of Nile red encapsulated FA-ONB-PXCLn micelles in response to irradiation. Light-triggered bursts released were observed for drug-loaded FA-ONB-PXCLn micelles. The nanoparticles exhibited nonsignificant toxicity at concentrations up to 300 mu g mL(-1). Flow cytometry revealed that the uptake of folate-targeted doxorubicin (DOX) -encapsulated micelles by HeLa cells was faster than that of free DOX.

引用

页码：53 / 63

页数：11

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