'Someday it will be the norm': physician perspectives on the utility of genome sequencing for patient care in the MedSeq Project

被引：33

作者：

Vassy, Jason L. ^{[1
,2
,3
]}

Christensen, Kurt D. ^{[3
,4
]}

Slashinski, Melody J. ^{[5
]}

Lautenbach, Denise M. ^{[3
,4
]}

Raghavan, Sridharan ^{[3
,6
]}

Robinson, Jill Oliver ^{[7
]}

Blumenthal-Barby, Jennifer ^{[7
]}

Feuerman, Lindsay Zausmer ^{[7
]}

Lehmann, Lisa Soleymani ^{[2
,3
,6
]}

Murray, Michael F. ^{[8
]}

Green, Robert C. ^{[3
,4
]}

McGuire, Amy L. ^{[7
]}

机构：

[1] VA Boston Healthcare Syst, Gen Internal Med Sect, Boston, MA 02130 USA

[2] Brigham & Womens Hosp, Dept Med, Div Gen Med & Primary Care, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[4] Brigham & Womens Hosp, Div Genet, Boston, MA 02115 USA

[5] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Amherst, MA 01003 USA

[6] Massachusetts Gen Hosp, Gen Med Div, Boston, MA 02114 USA

[7] Baylor Coll Med, Ctr Med Eth & Hlth Policy, Houston, TX 77030 USA

[8] Geisinger Hlth Syst, Danville, PA 17822 USA

来源：

PERSONALIZED MEDICINE | 2015年 / 12卷 / 01期

基金：

美国国家卫生研究院;

关键词：

genomics; high-throughput nucleotide sequencing; pharmacogenetics; physician's practice patterns; qualitative research; PERSONALIZED MEDICINE; CANCER; RISK; INFORMATION; PREVENTION; IMPACT;

D O I：

10.2217/PME.14.68

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: To describe practicing physicians' perceived clinical utility of genome sequencing. Materials & methods: We conducted a mixed-methods analysis of data from 18 primary care physicians and cardiologists in a study of the clinical integration of whole-genome sequencing. Physicians underwent brief genomics continuing medical education before completing surveys and semi-structured interviews. Results: Physicians described sequencing as currently lacking clinical utility because of its uncertain interpretation and limited impact on clinical decision-making, but they expressed the idea that its clinical integration was inevitable. Potential clinical uses for sequencing included complementing other clinical information, risk stratification, motivating patient behavior change and pharmacogenetics. Conclusion: Physicians given genomics continuing medical education use the language of both evidence-based and personalized medicine in describing the utility of genome-wide testing in patient care.

引用

页码：23 / 32

页数：10

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