Diimidazo[1,2-c:4′,5′-e]pyrimidines:: N6-N1 conformationally restricted adenosines

被引:6
作者
Camp, D [1 ]
Li, Y [1 ]
McCluskey, A [1 ]
Moni, RW [1 ]
Quinn, RJ [1 ]
机构
[1] Griffith Univ, Queensland Pharmaceut Res Inst, Brisbane, Qld 4111, Australia
基金
英国医学研究理事会;
关键词
D O I
10.1016/S0960-894X(98)00101-2
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Tethering the N-6-substituents of N-6-substituted adenosines to N1 has resulted in a series of conformationally restricted adenosine analogues. The resultant diimidazo[1,2-c:4',5'-e]pyrimidines were shown to be adenosine A(1) selective. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:695 / 698
页数:4
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