In Situ Alkyl Radical Recycling-Driven Decoupled Electrophotochemical Deamination

被引：37

作者：

Wang, Kui ^{[1
]}

Liu, Xiaoyu ^{[1
]}

Yang, Siyu ^{[1
]}

Tian, Yan ^{[1
]}

Zhou, Mingyang ^{[1
]}

Zhou, Jianhua ^{[1
]}

Jia, Xiaofei ^{[2
]}

Li, Baoying ^{[1
]}

Liu, Siyuan ^{[1
]}

Chen, Jianbin ^{[1
]}

机构：

[1] Qilu Univ Technol, Sch Chem & Chem Engn, Shandong Prov Key Lab Mol Engn, State Key Lab Biobased Mat & Green Papermaking,Sh, Jinan 250353, Peoples R China

[2] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Key Lab Opt Elect Sensing & Analyt Chem Life Sci, MOE, Qingdao 266042, Peoples R China

来源：

ORGANIC LETTERS | 2022年 / 24卷 / 19期

基金：

中国国家自然科学基金;

关键词：

SALTS; GENERATION; CATALYSIS;

D O I：

10.1021/acs.orglett.2c01022

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Molecular electrophotocatalysis has emerged as a powerful strategy for the development of sustainable synthetic protocols. With the proof-of-concept, we exploited a versatile electrophotocatalytic deaminative alkylation approach. Mechanistic investigation indicated that in situ recycling of the alkyl radicals was the key point. Notably, ligand modification and late-stage functionalization of pharmaceuticals were also established, highlighting its feasibility in practical utilization.

引用

页码：3471 / 3476

页数：6

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