Activated macrophages induce metastatic behavior of colon cancer cells

被引：78

作者：

Jedinak, Andrej ^{[1
]}

Dudhgaonkar, Shailesh ^{[1
]}

Sliva, Daniel ^{[1
,2
,3
]}

机构：

[1] Methodist Res Inst, Canc Res Lab, Indianapolis, IN 46202 USA

[2] Indiana Univ, Sch Med, Dept Med, Indianapolis, IN USA

[3] Indiana Univ, Sch Med, Simon Canc Ctr, Indianapolis, IN USA

来源：

IMMUNOBIOLOGY | 2010年 / 215卷 / 03期

关键词：

Macrophages; Colon cancer; Cell migration; Angiogenesis; NF-KAPPA-B; ENDOTHELIAL GROWTH-FACTOR; TUMOR-ASSOCIATED MACROPHAGES; INVASIVE BEHAVIOR; FACTOR EXPRESSION; P2X(7) RECEPTOR; HEPATOMA-CELLS; INFLAMMATION; AP-1; ANGIOGENESIS;

D O I：

10.1016/j.imbio.2009.03.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tumor-associated macrophages were linked to the growth, angiogenesis, and metastasis of variety of cancers. However, the role of macrophages in colon cancer is elusive. In the present study, we demonstrate that activated macrophage-conditioned medium (AMCM), containing tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and IL-6, markedly induced proliferation and migration of human colon cancer cells HCT116. Furthermore, AMCM significantly increased activation of transcription factor NF-kappa B and secretion of vascular endothelial growth factor (VEGF) from colon cancer cells, which subsequently induced capillary morphogenesis of human aortic endothelial cells. In conclusion, the interruption of signaling between activated macrophages and colon cancer cells could be considered as a new therapeutic strategy. (C) 2009 Elsevier GmbH. All rights reserved.

引用

页码：242 / 249

页数：8

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