A major triterpenoid saponin from Gypsophila oldhamiana

被引：34

作者：

Bai, Hong ^{[1
]}

Zhong, Ying ^{[1
]}

Xie, Yan-Ying ^{[1
]}

Wang, Yuan-Shu ^{[1
]}

Liu, Lu ^{[1
]}

Zhou, Ling ^{[1
]}

Wang, Ju ^{[1
]}

Mu, Yan-Ling ^{[1
]}

Zuo, Chun-Xu ^{[1
]}

机构：

[1] Acad Med Sci, Inst Mat Med, Shandong 250062, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2007年 / 4卷 / 05期

关键词：

D O I：

10.1002/cbdv.200790085

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new saponin, gypoldoside A (1), was isolated from the roots of Gypsophila oldhamiana. On the basis of in-depth NMR-spectroscopic and mass-spectrometric analysis, in combination with chemical evidence, its structure was established as 3-O-{beta-D-galactopyranosyl-(1-2)-(1 -> 2)-[beta-D-xylopyranosyl-(1 -> 3)]-beta-D-glucuronopyranosyl}quillaic acid 28-[alpha-L-arabinopyranosyl-(1 -> 2)-alpha-L-arabinopyranosyl-(1 -> 3)-beta-D-xylopyranosyl-(1 -> 4)-alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-fucopyranosyl] ester. Compound 1 was found to be highly active against three different human cancer cell lines, with IC50, values in the low micromolar range.

引用

页码：955 / 960

页数：6

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