DNA Microarray analysis of pancreatic malignancies

被引：40

作者：

Brandt, R

Grützmann, R

Bauer, A

Jesnowski, R

Ringel, J

Löhr, M

Pilarsky, C

Hoheisel, JD

机构：

[1] Deutsch Krebsforschungszentrum, Div Funct Genome Anal, DE-69120 Heidelberg, Germany

[2] Heidelberg Univ, Mannheim Med Fac, Dept Med 2, D-6900 Heidelberg, Germany

[3] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Visceral Thorac & Vasc Surg, Dresden, Germany

[4] Deutsch Krebsforschungszentrum, Mol Gastroenterol Unit, DE-69120 Heidelberg, Germany

来源：

PANCREATOLOGY | 2004年 / 4卷 / 06期

关键词：

pancreatic ductal carcinoma; microarray; gene expression profiling; cancer; pancreas;

D O I：

10.1159/000082241

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis. To improve the prognosis, novel molecular markers and targets for earlier diagnosis and adjuvant and/or neoadjuvant treatment are needed. Recent advances in human genome research and high-throughput molecular technologies make it possible to cope with the molecular complexity of malignant tumors. With DNA array technology, mRNA expression levels of thousand of genes can be measured simultaneously in a single assay. As several studies using microarrays in PDAC have already been published, this review attempts to compare the published data and therefore to validate the results. In addition, the applied techniques are discussed in the context of pancreatic malignancies. Copyright (C) 2004 S. Karger AG, Basel and IAP.

引用

页码：587 / 597

页数：11

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