The Value of Circulating Biomarkers in Bicuspid Aortic Valve-Associated Aortopathy

被引：9

作者：

Naito, Shiho ^{[1
]}

Hillebrand, Mathias ^{[2
]}

Bernhardt, Alexander Martin Justus ^{[3
]}

Jagodzinski, Annika ^{[2
]}

Conradi, Lenard ^{[3
]}

Detter, Christian ^{[3
]}

Sydow, Karsten ^{[2
]}

Reichenspurner, Hermann ^{[3
]}

von Kodolitsch, Yskert ^{[2
]}

Girdauskas, Evaldas ^{[3
]}

机构：

[1] Cent Hosp Bad Berka, Dept Cardiac Surg, Bad Berka, Germany

[2] Univ Heart Ctr Hamburg, Dept Cardiol, Hamburg, Germany

[3] Univ Heart Ctr Hamburg, Dept Cardiovasc Surg, Martinistr 52, D-20246 Hamburg, Germany

来源：

THORACIC AND CARDIOVASCULAR SURGEON | 2018年 / 66卷 / 04期

关键词：

bicuspid aortic valve; aortopathy; biomarkers; GLYCATION END-PRODUCTS; ASCENDING AORTA; MATRIX-METALLOPROTEINASE; ASYMMETRIC DIMETHYLARGININE; ALPHA-1-ANTITRYPSIN DEFICIENCY; PHENOTYPIC CLASSIFICATION; CARDIOVASCULAR-DISEASE; TISSUE INHIBITOR; MARFAN-SYNDROME; ANEURYSM;

D O I：

10.1055/s-0036-1583525

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Traditional risk stratification model of bicuspid aortic valve (BAV) aortopathy is based on measurement of maximal cross-sectional aortic diameter, definition of proximal aortic shape, and aortic stiffness/elasticity parameters. However, conventional imaging-based criteria are unable to provide reliable information regarding the risk stratification in BAV aortopathy, especially considering the heterogeneous nature of BAV disease. Given those limitations of conventional imaging, there is a growing clinical interest to use circulating biomarkers in the screening process for thoracic aortic aneurysms as well as in the risk-assessment algorithms. We aimed to systematically review currently available biomarkers, which may be of value to predict the natural evolution of aortopathy in individuals with BAV.

引用

页码：278 / 286

页数：9

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