Gold nanoprisms for photothermal cell ablation in vivo

被引：0

作者：

Ambrosone, Alfredo ^{[1
]}

del Pino, Pablo ^{[2
]}

Marchesano, Valentina ^{[1
]}

Parak, Wolfgang J. ^{[3
]}

de la Fuente, Jesus M. ^{[2
]}

Tortiglione, Claudia ^{[1
]}

机构：

[1] CNR, Ist Cibernet E Caianiello, I-80078 Pozzuoli, Italy

[2] Univ Zaragoza, Inst Nanociencia Aragon, Zaragoza, Spain

[3] Univ Marburg, FB Phys, D-35037 Marburg, Germany

来源：

NANOMEDICINE | 2014年 / 9卷 / 13期

关键词：

gold nanoparticles; Hydra vulgaris; hyperthermia; model organism; near-infrared light; photothermal cell ablation; RESONANCE-INDUCED PHOTOACTIVATION; CAENORHABDITIS-ELEGANS; STRESS-RESPONSE; DRUG-RELEASE; NANOPARTICLES; HYDRA; THERAPY; CANCER; HYPERTHERMIA; EXPRESSION;

D O I：

10.2217/NNM.14.100

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: To develop new methodologies for selective cell ablation in a temporally and spatially precise fashion in model organisms. Materials & methods: living polyps (Hydra vulgaris) treated with gold nanoprisms were near-infrared (NIR) irradiated and the photothermal effects evaluated at whole-animal, cellular and molecular levels. Results: Nanoprisms showed good efficiency of internalization in living specimens, with no sign of toxicity; under NIR irradiation they induced cell death and the overexpression of the hsp70 gene. Conclusion: gold nanoprisms could be employed as efficient heat mediators in model organisms, and NIR-triggered cell ablation may represent a new advanced tool to study cell function. Solving bioethical and economical issues, invertebrates may provide alternative models bridging the gap between cell research and preclinical studies of photothermal therapy.

引用

页码：1913 / 1922

页数：10

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