Infectious agents and inflammation in donated hearts and dilated cardiomyopathies related to cardiovascular diseases, Chagas' heart disease, primary and secondary dilated cardiomyopathies

被引：16

作者：

Mangini, Sandrigo ^{[1
]}

Higuchi, Maria de Lourdes ^{[1
]}

Kawakami, Joyce Tiyeko ^{[1
]}

Reis, Marcia Martins ^{[1
]}

Ikegami, Renata Nishiyama ^{[1
]}

Pinheiro Palomino, Suely Aparecida ^{[1
]}

Alberto Pomerantzeff, Pablo Maria ^{[1
]}

Fiorelli, Alfredo Inacio ^{[1
]}

Marcondes-Braga, Fabiana Goulart ^{[1
]}

Bacal, Fernando ^{[1
]}

Ayub Ferreira, Silvia Moreira ^{[1
]}

Issa, Victor Sarli ^{[1
]}

Conceicao Souza, Germano Emilio ^{[1
]}

Chizzola, Paulo Roberto ^{[1
]}

Bocchi, Edimar Alcides ^{[1
]}

机构：

[1] Univ Sao Paulo, Hosp Clin, Fac Med, Heart Inst InCor, BR-05508 Sao Paulo, Brazil

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2015年 / 178卷

关键词：

Myocarditis; Heart failure; Heart donors; Dilated cardiomyopathy; Chagas' heart disease; Endomyocardial biopsy; HEPATITIS-C VIRUS; HYPERTROPHIC CARDIOMYOPATHY; ENTEROVIRUS PERSISTENCE; ENDOMYOCARDIAL BIOPSIES; MOLECULAR DIAGNOSIS; VIRAL-INFECTIONS; HIGH PREVALENCE; MYOCARDITIS; ASSOCIATION; TRANSPLANTATION;

D O I：

10.1016/j.ijcard.2014.10.133

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Clinical and experimental conflicting data have questioned the relationship between infectious agents, inflammation and dilated cardiomyopathy (DCM). Objectives: The aim of this study was to determine the frequency of infectious agents and inflammation in endomyocardial biopsy (EMB) specimens from patients with idiopathic DCM, explanted hearts from different etiologies, including Chagas' disease, compared to donated hearts. Methods: From 2008 to 2011, myocardial samples from 29 heart donors and 55 patients with DCMs from different etiologies were studied (32 idiopathic, 9 chagasic, 6 ischemic and 8 other specific etiologies). Inflammation was investigated by immunohistochemistry and infectious agents by immunohistochemistry, molecular biology, in situ hybridization and electron microscopy. Results: There were no differences regarding the presence of macrophages, expression of HLA class II and ICAM-I in donors and DCM. Inflammation in Chagas' disease was predominant. By immunohistochemistry, in donors, there was a higher expression of antigens of enterovirus and Borrelia, hepatitis B and C in DCMs. By molecular biology, in all groups, the positivity was elevated to microorganisms, including co-infections, with a higher positivity to adenovirus and HHV6 in donors towards DCMs. This study was the first to demonstrate the presence of virus in the heart tissue of chagasic DCM. Conclusions: The presence of inflammation and infectious agents is frequent in donated hearts, in the myocardium of patients with idiopathic DCM, myocardial dysfunction related to cardiovascular diseases, and primary and secondary cardiomyopathies, including Chagas' disease. The role of co-infection in Chagas' heart disease physiopathology deserves to be investigated in future studies. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：55 / 62

页数：8

共 44 条

[21] Detection of viral genome in the myocardium:: Lack of prognostic and functional relevance in patients with acute dilated cardiomyopathy [J].

Kuethe, Friedhelm ;

Sigusch, Holger H. ;

Hilbig, Kristina ;

Tresselt, Christiane ;

Glueck, Brigitte ;

Egerer, Renate ;

Figulla, Hans R. .

AMERICAN HEART JOURNAL, 2007, 153 (05) :850-858

[22] Viral persistence in the myocardium is associated with progressive cardiac dysfunction [J].

Kühl, U ;

Pauschinger, M ;

Seeberg, B ;

Lassner, D ;

Noutsias, M ;

Poller, W ;

Schultheiss, HPP .

CIRCULATION, 2005, 112 (13) :1965-1970

[23] High prevalence of viral genomes and multiple viral infections in the myocardium of adults with "idiopathic" left ventricular dysfunction [J].

Kühl, U ;

Pauschinger, M ;

Noutsias, M ;

Seeberg, B ;

Bock, T ;

Lassner, D ;

Poller, W ;

Kandolf, R ;

Schultheiss, HP .

CIRCULATION, 2005, 111 (07) :887-893

[24] A distinct subgroup of cardiomyopathy patients characterized by transcriptionally active cardiotropic erythrovirus and altered cardiac gene expression [J].

Kuhl, U. ;

Lassner, D. ;

Dorner, A. ;

Rohde, M. ;

Escher, F. ;

Seeberg, B. ;

Hertel, E. ;

Tschope, C. ;

Skurk, C. ;

Gross, U. M. ;

Schultheiss, H. -P. ;

Poller, W. .

BASIC RESEARCH IN CARDIOLOGY, 2013, 108 (05)

[25] Current understanding of immunity to Trypanosoma cruzi infection and pathogenesis of Chagas disease [J].

Machado, Fabiana S. ;

Dutra, Walderez O. ;

Esper, Lisia ;

Gollob, Kenneth J. ;

Teixeira, Mauro M. ;

Factor, Stephen M. ;

Weiss, Louis M. ;

Nagajyothi, Fnu ;

Tanowitz, Herbert B. ;

Garg, Nisha J. .

SEMINARS IN IMMUNOPATHOLOGY, 2012, 34 (06) :753-770

[26] High prevalence of cardiotropic viruses in myocardial tissue from explanted hearts of heart transplant recipients and heart donors:: A 3-year retrospective study from a German patients' pool [J].

Mantke, OD ;

Meyer, R ;

Prösch, S ;

Nitsche, A ;

Leitmeyer, K ;

Kallies, R ;

Niedrig, M .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2005, 24 (10) :1632-1638

[27] Contemporary definitions and classification of the cardiomyopathies - An American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; And Council on Epidemiology and Prevention [J].

Maron, BJ ;

Towbin, JA ;

Thiene, G ;

Antzelevitch, C ;

Corrado, D ;

Arnett, D ;

Moss, AJ ;

Seidman, CE ;

Young, JB .

CIRCULATION, 2006, 113 (14) :1807-1816

[28] Hepatitis C virus from the hearts of patients with myocarditis and cardiomyopathy [J].

Matsumori, A ;

Yutani, C ;

Ikeda, Y ;

Kawai, S ;

Sasayama, S .

LABORATORY INVESTIGATION, 2000, 80 (07) :1137-1142

[29] Detection of hepatitis C virus RNA from the heart of patients with hypertrophic cardiomyopathy [J].

Matsumori, A ;

Matoba, Y ;

Nishio, R ;

Shioi, T ;

Ono, K ;

Sasayama, S .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 222 (03) :678-682

[30] DILATED CARDIOMYOPATHY ASSOCIATED WITH HEPATITIS-C VIRUS-INFECTION [J].

MATSUMORI, A ;

MATOBA, Y ;

SASAYAMA, S .

CIRCULATION, 1995, 92 (09) :2519-2525

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