Discrimination of cathinone regioisomers, sold as 'legal highs', by Raman spectroscopy

被引：39

作者：

Christie, R. ^{[1
,2
]}

Horan, E. ^{[2
]}

Fox, J. ^{[2
]}

O'Donnell, C. ^{[2
]}

Byrne, H. J. ^{[1
]}

McDermott, S. ^{[3
]}

Power, J. ^{[3
]}

Kavanagh, P. ^{[4
]}

机构：

[1] Dublin Inst Technol, Focas Res Inst, Dublin 8, Ireland

[2] Dublin Inst Technol, Sch Chem & Pharmaceut Sci, Dublin 8, Ireland

[3] Garda HQ, Forens Sci Lab, Dublin 8, Ireland

[4] St James Hosp, Dept Pharmacol & Therapeut, Sch Med, Trinity Ctr Hlth Sci, Dublin 8, Ireland

来源：

DRUG TESTING AND ANALYSIS | 2014年 / 6卷 / 7-8期

关键词：

Raman; flephedrone; mephedrone; methylone; MDPV; naphyrone; ECSTASY TABLETS; ABUSE;

D O I：

10.1002/dta.1518

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The discrimination of a cross section of cathinone regioisomers, sold as 'legal highs', using Raman spectroscopy, is reported here. Mephedrone and flephedrone were identified in 'legal high' products sold in Irish head shops, and their 2, 3 and 4-isomers were synthesized as reference standards. The 3,4-methylenedioxy substituted cathinones, methylone, butylone and methylenedioxypyrovalerone (MDPV), were also identified in 'legal highs' and their 2,3-isomers were synthesized for comparison. In addition, alpha-and beta-naphyrone were synthesized. Raman spectra of all the isomers were obtained using far-red excitation (785 nm) and it was found possible to discriminate the isomers of each substituted cathinone. In addition, Raman spectra were also recorded for a number of head shop products and, by comparison with the reference standards, correct isomer assignment for 4-mephedrone, 3-flephedrone, 3,4-methylone, 3,4-butylone, 3,4-MDPV, alpha-naphyrone and beta-naphyrone was achieved, thus providing a non-destructive, high-throughput and minimal sample preparation technique for the discrimination of such drug isomers. Copyright (C) 2013 John Wiley & Sons, Ltd.

引用

页码：651 / 657

页数：7

共 20 条

[1]

[Anonymous], 1980, Infrared Characteristic Group Frequencies

[2] Fluoromethcathinone, a new substance of abuse [J].

Archer, R. P. .

FORENSIC SCIENCE INTERNATIONAL, 2009, 185 (1-3) :10-20

[3] Composition profiling of seized ecstasy tablets by Raman spectroscopy [J].

Bell, SEJ ;

Burns, DT ;

Dennis, AC ;

Matchett, LJ ;

Speers, JS .

ANALYST, 2000, 125 (10) :1811-1815

[4] Tracking the distribution of "ecstasy" tablets by Raman composition profiling: A large scale feasibility study [J].

Bell, SEJ ;

Barrett, LJ ;

Burns, DT ;

Dennis, AC ;

Speers, SJ .

ANALYST, 2003, 128 (11) :1331-1335

[5] Forensic Chemistry [J].

Bell, Suzanne .

ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, 2009, 2 :297-319

[6] Analytical characterization of three trifluoromethyl-substituted methcathinone isomers [J].

Brandt, Simon D. ;

Daley, Paul F. ;

Cozzi, Nicholas V. .

DRUG TESTING AND ANALYSIS, 2012, 4 (06) :525-529

[7]

Burnett A.D., 2011, DRUG TEST ANAL, V9, P539

[8]

Chalmers J.M., 2012, Infrared and Raman spectroscopy in forensic science, DOI DOI 10.1002/9781119962328.CH3

[9]

European Monitoring Center for Drugs and Drug Addiction (EMCDDA), SYNTH CATH

[10] Analysis of seized drugs using portable Raman spectroscopy in an airport environment - a proof of principle study [J].

Hargreaves, Michael D. ;

Page, Kristian ;

Munshi, Tasnim ;

Tomsett, Richard ;

Lynch, Gary ;

Edwards, Howell G. M. .

JOURNAL OF RAMAN SPECTROSCOPY, 2008, 39 (07) :873-880

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