Effect of superfine pulverization on physicochemical and medicinal properties of Qili Powder

被引：17

作者：

Zhao, Guowei ^{[1
,2
]}

Liang, Xinli ^{[1
]}

Wang, Chunliu ^{[3
]}

Liao, Zhenggen ^{[1
]}

Xiong, Zhiwei ^{[1
]}

Li, Zhe ^{[1
]}

机构：

[1] JiangXi Univ Tradit Chinese Med, Minist Educ, Key Lab Modern Preparat Tradit Chinese Med, Nanchang, Peoples R China

[2] Shaanxi Normal Univ, Sch Chem & Chem Engn, Minist Educ, Key Lab Appl Surface & Colloid Chem, Xian, Peoples R China

[3] Shannxi Acad Tradit Chinese Med, Xian, Peoples R China

来源：

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2014年 / 24卷 / 05期

关键词：

Medicinal properties; Physicochemical properties; Qili Powder; Superfine pulverization; DRAGONS BLOOD;

D O I：

10.1016/j.bjp.2014.09.006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Qili Powder, a preparation from Traditional Chinese Medicine, commonly used to treat injuries from falling or stumbling, pain caused by bruising, and traumatic hemorrhage. The aim of the present work was to investigate the application of the superfine pulverization on Qili Powder properties. The physicochemical and medicinal properties of fine Qili Powder with D-90 particle size of 164.5 mu m, and superfine Qili Powder with D-90 particle size of 32.2 mu m were investigated. The results showed that with decreasing particle size, the specific surface area and pore volume increased, the fluidity decreased, and the percentage of moisture absorption and the balanced moisture content decreased. Analysis HPLC, XRD and FTIR results indicated that superfine pulverization didn't influence dracorhodin content, nor the molecular structure and crystal form of Qili Powder. The percentage of dissolution of dracorhodin was significantly improved after superfine pulverization. Pharmacokinetics results confirmed that superfine pulverization increases the absorption rate in rats and dracorhodin content of Qili Powder. (C) 2014 Sociedade Brasileira de Farmacognosia. Published by Elsevier Editora Ltda. All rights reserved.

引用

页码：584 / 590

页数：7

共 22 条

[1]

[Anonymous], 2010, PHARMACOPOEIA PEOPLE

[2]

[Anonymous], CHIN J CLIN REHABILI

[3] Preparation and characterization of crosslinked porous cellulose beads [J].

Bai, Yong-Xiao ;

Li, Yan-Feng .

CARBOHYDRATE POLYMERS, 2006, 64 (03) :402-407

[4] The angle of repose of bulk corn stover particles [J].

Ileleji, K. E. ;

Zhou, B. .

POWDER TECHNOLOGY, 2008, 187 (02) :110-118

[5] Chinese medicine and its modernization demands [J].

Li, Wei-Feng ;

Jiang, Jian-Guo ;

Chen, Jian .

ARCHIVES OF MEDICAL RESEARCH, 2008, 39 (02) :246-251

[6]

[廖正根 Liao Zhenggen], 2010, [中国药学杂志, Chinese Pharmaceutical Journal], V45, P602

[7]

[马建建 Ma Jianjian], 2002, [中草药, Chinese Traditional and Herbal Drugs], V33, P1008

[8] Modification of physicochemical and medicinal characterization of Liuwei Dihuang particles by ultrafine grinding [J].

Ma, P. Y. ;

Fu, Z. Y. ;

Su, Y. L. ;

Zhang, J. Y. ;

Wang, W. M. ;

Wang, H. ;

Wang, Y. C. ;

Zhang, Q. J. .

POWDER TECHNOLOGY, 2009, 191 (1-2) :194-199

[9] Surface properties of yam (Dioscorea sp.) starch powders and potential for use as binders and disintegrants in drug formulations [J].

Riley, Cliff K. ;

Adebayo, Sarafadeen A. ;

Wheatley, Andrew O. ;

Asemota, Helen N. .

POWDER TECHNOLOGY, 2008, 185 (03) :280-285

[10] Powder flowability and density ratios: the impact of granules packing [J].

Santomaso, A ;

Lazzaro, P ;

Canu, P .

CHEMICAL ENGINEERING SCIENCE, 2003, 58 (13) :2857-2874

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