BrachyView: multiple seed position reconstruction and comparison with CT post-implant dosimetry

被引：4

作者：

Alnaghy, S. ^{[1
]}

Loo, K. J. ^{[1
,4
]}

Cutajar, D. L. ^{[1
]}

Jalayer, M. ^{[1
]}

Tenconi, C. ^{[2
]}

Favoino, M. ^{[7
]}

Rietti, R. ^{[7
]}

Tartaglia, M. ^{[7
]}

Carriero, F. ^{[7
]}

Safavi-Naeini, M. ^{[1
]}

Bucci, J. ^{[3
]}

Jakubek, J. ^{[5
]}

Pospisil, S. ^{[4
]}

Zaider, M. ^{[6
]}

Lerch, M. L. F. ^{[1
]}

Rosenfeld, A. B. ^{[1
]}

Petasecca, M. ^{[1
]}

机构：

[1] Univ Wollongong, Ctr Med Radiat Phys, Northfields Ave, Wollongong, NSW, Australia

[2] Fdn IRCCS Ist Nazl Tumori, Med Phys Unit, Milan, Italy

[3] St George Hosp, St George Canc Care Ctr, Gray St, Kogarah, NSW, Australia

[4] Czech Tech Univ, Inst Expt & Appl Phys, Zikova 1903-4, CR-16635 Prague 6, Czech Republic

[5] Advacam, Prague 3, Czech Republic

[6] Mem Sloan Kettering Canc Ctr, Brachytherapy Phys, York Ave, New York, NY USA

[7] Adv Comp Syst, Via Bufalotta, Rome, Italy

来源：

JOURNAL OF INSTRUMENTATION | 2016年 / 11卷

基金：

英国医学研究理事会;

关键词：

Intra-operative probes; Dosimetry concepts and apparatus; Instrumentation for gamma-electron therapy; X-ray detectors; PERMANENT PROSTATE BRACHYTHERAPY; PIXEL READOUT CHIP; AMERICAN-BRACHYTHERAPY; QUALITY; TIME; ARM; GUIDANCE; SOCIETY; FUSION; CANCER;

D O I：

10.1088/1748-0221/11/05/P05002

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

BrachyView is a novel in-body imaging system utilising high-resolution pixelated silicon detectors (Timepix) and a pinhole collimator for brachytherapy source localisation. Recent studies have investigated various options for real-time intraoperative dynamic dose treatment planning to increase the quality of implants. In a previous proof-of-concept study, the justification of the pinhole concept was shown, allowing for the next step whereby multiple active seeds are implanted into a PMMA phantom to simulate a more realistic clinical scenario. In this study, 20 seeds were implanted and imaged using a lead pinhole of 400 mu m diameter. BrachyView was able to resolve the seed positions within 1-2 mm of expected positions, which was verified by co-registering with a full clinical post-implant CT scan.

引用

页数：16

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