Metal-free synthesis of highly substituted quinolines under mild conditions

被引：9
|
作者：
Natarajan, Rakesh [1 ]
Unnikrishnan, Peruparambil A. [1 ]
Radhamani, Sandhya [2 ]
Rappai, John P. [3 ]
Prathapan, Sreedharan [1 ]
机构：
[1] Cochin Univ Sci & Technol, Dept Appl Chem, Kochi 682022, Kerala, India
[2] NSS Coll, Dept Chem, Ottapalam 679103, Palakkad, India
[3] Govt Victoria Coll, Dept Chem, Palakkad 678001, India
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 27-28期
关键词：
Nitrones; Quinolines; Electron deficient acetylenes; Fluorenone; 1,3-Dloplar addition; POLYSUBSTITUTED QUINOLINES; CATALYZED SYNTHESIS; ALCOHOLS; QUINAZOLINE; KETONES;
D O I：
10.1016/j.tetlet.2016.05.091
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Starting from easily accessible nitrones and acetylenes, a simple, metal free synthesis of substituted quinolines under mild conditions with high atom efficiency has been developed. Our method is flexible enough to introduce substituents regiospecifically at the 2,3,4,6,8-positions of the quinoline product. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2981 / 2984
页数：4
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