microRNAs Are Key Regulators in Chronic Lung Disease: Exploring the Vital Link between Disease Progression and Lung Cancer

被引：6

作者：

Eapen, Mathew Suji ^{[1
]}

McAlinden, Kielan Darcy ^{[1
]}

Myers, Stephen ^{[1
]}

Lu, Wenying ^{[1
]}

Sohal, Sukhwinder Singh ^{[1
]}

机构：

[1] Univ Tasmania, Sch Hlth Sci, Dept Lab Med, Resp Translat Res Grp, Launceston, Tas 7248, Australia

来源：

JOURNAL OF CLINICAL MEDICINE | 2019年 / 8卷 / 11期

关键词：

microRNA; COPD; lung cancer; EPITHELIAL-MESENCHYMAL TRANSITION; MIR-200; FAMILY; FREE-RADICALS; EXPRESSION; SMOKING; BIOMARKERS; HISTOLOGY; BLOCKADE; SMOKERS; DAMAGE;

D O I：

10.3390/jcm8111986

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

microRNAs (miRNAs) bind to mRNAs and inhibit their expression through post-transcriptionally regulating gene expression. Here, we elaborate upon the concise summary of the role of miRNAs in carcinogenesis with specific attention to precursor respiratory pathogenesis caused by cigarette smoke modulation of these miRNAs. We review how miRNAs are implicated in cigarette-smoke-driven mechanisms, such as epithelial to mesenchymal transition, autophagy modulation, and lung ageing, which are important in the development of chronic obstructive pulmonary disease and potential progression to lung cancer. Extracellular vesicles are key to inter-cellular communication and sharing of miRNAs. A deeper understanding of the role of miRNAs in chronic respiratory disease and their use as clinical biomarkers has great potential. Therapeutic targeting of miRNAs may significantly benefit the prevention of cancer progression.

引用

收藏

页数：6

相关论文

共 50 条

[11] Chronic obstructive pulmonary disease and interstitial lung disease in patients with lung cancer [J].

Mizuno, Satoko ;

Takiguchi, Yuichi ;

Fujikawa, Ayako ;

Motoori, Ken ;

Tada, Yuji ;

Kurosu, Katsushi ;

Sekine, Yasuo ;

Yanagawa, Noriyuki ;

Hiroshima, Kenzo ;

Muraoka, Katsumi ;

Mitsushima, Toru ;

Niki, Noboru ;

Tanabe, Nobuhiro ;

Tatsumi, Koichiro ;

Kuriyama, Takayuki .

RESPIROLOGY, 2009, 14 (03) :377-383

[12] Protein phosphatase 2A (PP2A): a key phosphatase in the progression of chronic obstructive pulmonary disease (COPD) to lung cancer [J].

Nader, Cassandra P. ;

Cidem, Aylin ;

Verrills, Nicole M. ;

Ammit, Alaina J. .

RESPIRATORY RESEARCH, 2019, 20 (01)

[13] Common Mechanisms Linking Chronic Obstructive Pulmonary Disease and Lung Cancer [J].

Houghton, A. McGarry .

ANNALS OF THE AMERICAN THORACIC SOCIETY, 2018, 15 :S273-S277

[14] MicroRNAs: Emerging oncogenic and tumor-suppressive regulators, biomarkers and therapeutic targets in lung cancer [J].

Tang, Shengjie ;

Li, Shuangjiang ;

Liu, Tao ;

He, Yiwei ;

Hu, Haiyang ;

Zhu, Yunhe ;

Tang, Shoujun ;

Zhou, Haining .

CANCER LETTERS, 2021, 502 :71-83

[15] Genomic mechanisms of transformation from chronic obstructive pulmonary disease to lung cancer [J].

Wang, Diane C. ;

Shi, Lin ;

Zhu, Zhenhua ;

Gao, Danyan ;

Zhang, Yong .

SEMINARS IN CANCER BIOLOGY, 2017, 42 :52-59

[16] Chronic Obstructive Pulmonary Disease: Epidemiology, Biomarkers, and Paving the Way to Lung Cancer [J].

Szalontai, Klara ;

Gemes, Nikolett ;

Furak, Jozsef ;

Varga, Tunde ;

Neuperger, Patricia ;

Balog, Jozsef A. ;

Puskas, Laszlo G. ;

Szebeni, Gabor J. .

JOURNAL OF CLINICAL MEDICINE, 2021, 10 (13)

[17] The role of microRNAs in lung cancer progression [J].

Wen-Cheng Zhang ;

Jinbo Liu ;

Xiangying Xu ;

Guangshun Wang .

Medical Oncology, 2013, 30

[18] The role of microRNAs in lung cancer progression [J].

Zhang, Wen-Cheng ;

Liu, Jinbo ;

Xu, Xiangying ;

Wang, Guangshun .

MEDICAL ONCOLOGY, 2013, 30 (03)

[19] Collagenolytic Matrix Metalloproteinases in Chronic Obstructive Lung Disease and Cancer [J].

Woode, Denzel ;

Shiomi, Takayuki ;

D'Armiento, Jeanine .

CANCERS, 2015, 7 (01) :329-341

[20] MicroRNAs: a new key in lung cancer [J].

Yunlong Zhang ;

Qian Yang ;

Siwang Wang .

Cancer Chemotherapy and Pharmacology, 2014, 74 :1105-1111

← 1 2 3 4 5 →