Two-Headed PROTAC: An Effective New Tool for Targeted Protein Degradation

被引：47

作者：

Cyrus, Kedra ^{[1
]}

Wehenkel, Marie ^{[1
]}

Choi, Eun-Young ^{[2
]}

Swanson, Hollie ^{[2
]}

Kim, Kyung-Bo ^{[1
]}

机构：

[1] Univ Kentucky, Dept Pharmaceut Sci, Lexington, KY 40536 USA

[2] Univ Kentucky, Dept Mol & Biomed Pharmacol, Lexington, KY 40536 USA

来源：

CHEMBIOCHEM | 2010年 / 11卷 / 11期

关键词：

estrogen receptor; ligases; PROTAC; proteomics; ubiquitin-proteasome pathway; ARYL-HYDROCARBON RECEPTOR; CHIMERIC MOLECULES; CHEMICAL GENETICS; UBIQUITINATION; BINDING; SCF;

D O I：

10.1002/cbic.201000222

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Better than one: A novel class of PROTAC that recruits target protein for ubiquitination and subsequent degradation by the proteasome has been successfully synthesized and tested for its activity to degrade a target protein. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1531 / 1534

页数：4

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