Two-Headed PROTAC: An Effective New Tool for Targeted Protein Degradation

被引：43
作者：
Cyrus, Kedra [1 ]
Wehenkel, Marie [1 ]
Choi, Eun-Young [2 ]
Swanson, Hollie [2 ]
Kim, Kyung-Bo [1 ]
机构：
[1] Univ Kentucky, Dept Pharmaceut Sci, Lexington, KY 40536 USA
[2] Univ Kentucky, Dept Mol & Biomed Pharmacol, Lexington, KY 40536 USA
来源：
CHEMBIOCHEM | 2010年 / 11卷 / 11期
关键词：
estrogen receptor; ligases; PROTAC; proteomics; ubiquitin-proteasome pathway; ARYL-HYDROCARBON RECEPTOR; CHIMERIC MOLECULES; CHEMICAL GENETICS; UBIQUITINATION; BINDING; SCF;
D O I：
10.1002/cbic.201000222
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Better than one: A novel class of PROTAC that recruits target protein for ubiquitination and subsequent degradation by the proteasome has been successfully synthesized and tested for its activity to degrade a target protein. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：1531 / 1534
页数：4
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