Role of Annexin A1 in Squamous Cell Lung Cancer Progression

被引：7

作者：

Elakad, Omar ^{[1
]}

Li, Yuchan ^{[1
]}

Gieser, Natascha ^{[1
]}

Yao, Sha ^{[1
]}

Kueffer, Stefan ^{[1
]}

Hinterthaner, Marc ^{[2
]}

Danner, Bernhard C. ^{[2
]}

von Hammerstein-Equord, Alexander ^{[2
]}

Stroebel, Philipp ^{[1
]}

Bohnenberger, Hanibal ^{[1
]}

机构：

[1] Univ Med Ctr, Inst Pathol, Gottingen, Germany

[2] Univ Med Ctr, Dept Thorac & Cardiovasc Surg, Gottingen, Germany

来源：

DISEASE MARKERS | 2021年 / 2021卷

关键词：

BREAST-CANCER; PERITONEAL DISSEMINATION; EXPRESSION; METASTASIS; ANXA1; TUMOR; PROLIFERATION; INFLAMMATION; CARCINOMA; PROTEINS;

D O I：

10.1155/2021/5520832

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Lung cancer remains the primary cause of cancer-related death worldwide, and its molecular mechanisms of tumor progression need further characterization to improve the clinical management of affected patients. The role of Annexin A1 (ANXA1) in tumorigenesis and cancer progression in general and especially in lung cancer remains to be controversial and seems to be highly tissue specific and inconsistent among tumor initiation, progression, and metastasis. In the current study, we investigated ANXA1 expression in 81 squamous cell lung cancer (SQCLC), 86 pulmonary adenocarcinoma (AC), and 30 small cell lung cancer (SCLC) patient-derived tissue samples and its prognostic impact on patient's survival. Mechanistically, we analyzed the impact of ANXA1 expression on proliferation and migration of SQCLC cell lines using CRISPR-Cas9 and mammalian overexpression vectors. Strong expression of ANXA1 was significantly correlated to longer overall survival only in SQCLC patients (P=0.019). Overexpression of ANXA1 promoted proliferation in SQCLC cell lines but suppressed their migration, while knockout of ANXA1 promoted cell migration and suppressed proliferation. In conclusion, ANXA1 expression might elongate patients' survival by inhibiting tumor cell migration and subsequent metastasis.

引用

页数：10

共 44 条

[1] Lung Cancer Worldwide [J].

Adjei, Alex A. .

JOURNAL OF THORACIC ONCOLOGY, 2019, 14 (06) :956-956

[2] Annexin-Phospholipid Interactions. Functional Implications [J].

Antonia Lizarbe, Maria ;

Barrasa, Juan I. ;

Olmo, Nieves ;

Gavilanes, Francisco ;

Turnay, Javier .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 14 (02) :2652-2683

[3] Extracellular annexin-A1 promotes myeloid/granulocytic differentiation of hematopoietic stem/progenitor cells via the Ca2+/MAPK signalling transduction pathway [J].

Barbosa, Christiano M., V ;

Fock, Ricardo Ambrosio ;

Hastreiter, Araceli Aparecida ;

Reutelingsperger, Cris ;

Perretti, Mauro ;

Paredes-Gamero, Edgar J. ;

Farsky, Sandra H. P. .

CELL DEATH DISCOVERY, 2019, 5 (1)

[4] Annexin A1 contributes to pancreatic cancer cell phenotype, behaviour and metastatic potential independently of Formyl Peptide Receptor pathway [J].

Belvedere, Raffaella ;

Bizzarro, Valentina ;

Forte, Giovanni ;

Dal Piaz, Fabrizio ;

Parente, Luca ;

Petrella, Antonello .

SCIENTIFIC REPORTS, 2016, 6

[5] Loss of ARID1A Activates ANXA1, which Serves as a Predictive Biomarker for Trastuzumab Resistance [J].

Berns, Katrien ;

Sonnenblick, Amir ;

Gennissen, Annemiek ;

Brohee, Sylvain ;

Hijmans, E. Marielle ;

Evers, Bastiaan ;

Fumagalli, Debora ;

Desmedt, Christine ;

Loibl, Sibylle ;

Denkert, Carsten ;

Neven, Patrick ;

Guo, Wei ;

Zhang, Fan ;

Knijnenburg, Theo A. ;

Bosse, Tjalling ;

van der Heijden, Michiel S. ;

Hindriksen, Sanne ;

Nijkamp, Wouter ;

Wessels, Lodewyk F. A. ;

Joensuu, Heikki ;

Mills, Gordon B. ;

Beijersbergen, Roderick L. ;

Sotiriou, Christos ;

Bernards, Rene .

CLINICAL CANCER RESEARCH, 2016, 22 (21) :5238-5248

[6] Annexin A1 is involved in the acquisition and maintenance of a stem cell-like/aggressive phenotype in prostate cancer cells with acquired resistance to zoledronic acid [J].

Bizzarro, Valentina ;

Belvedere, Raffaella ;

Milone, Maria Rita ;

Pucci, Biagio ;

Lombardi, Rita ;

Bruzzese, Francesca ;

Popolo, Ada ;

Parente, Luca ;

Budillon, Alfredo ;

Petrella, Antonello .

ONCOTARGET, 2015, 6 (28) :25074-25092

[7] Annexin A1 in primary tumors promotes melanoma dissemination [J].

Boudhraa, Zied ;

Rondepierre, Fabien ;

Ouchchane, Lemlih ;

Kintossou, Roselyne ;

Trzeciakiewicz, Anna ;

Franck, Frederic ;

Kanitakis, Jean ;

Labeille, Bruno ;

Joubert-Zakeyh, Juliette ;

Bouchon, Bernadette ;

Perrot, Jean Luc ;

Mansard, Sandrine ;

Papon, Janine ;

Dechelotte, Pierre ;

Chezal, Jean-Michel ;

Miot-Noirault, Elisabeth ;

Bonnet, Mathilde ;

D'Incan, Michel ;

Degoul, Francoise .

CLINICAL & EXPERIMENTAL METASTASIS, 2014, 31 (07) :749-760

[8] Annexin A1 regulates TGF-β signaling and promotes metastasis formation of basal-like breast cancer cells [J].

de Graauw, Marjo ;

van Miltenburg, Martine H. ;

Schmidt, Marjanka K. ;

Pont, Chantal ;

Lalai, Reshma ;

Kartopawiro, Joelle ;

Pardali, Evangelia ;

Le Devedec, Sylvia E. ;

Smit, Vincent T. ;

van der Wal, Annemieke ;

Van't Veer, Laura J. ;

Cleton-Jansen, Anne-Marie ;

ten Dijke, Peter ;

van de Water, Bob .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (14) :6340-6345

[9] Annexin A1, A2, A4 and A5 play important roles in breast cancer, pancreatic cancer and laryngeal carcinoma, alone and/or synergistically [J].

Deng, Shishan ;

Wang, Jianguo ;

Hou, Lingmi ;

Li, Jinsui ;

Chen, Guo ;

Jing, Baoqian ;

Zhang, Xiaoming ;

Yang, Zhengwei .

ONCOLOGY LETTERS, 2013, 5 (01) :107-112

[10] Knockdown of ANXA1 suppresses the biological behavior of human NSCLC cells in vitro [J].

Fang, Ying ;

Guan, Xiaoying ;

Cai, Tonghui ;

Long, Jie ;

Wang, Hongyan ;

Xie, Xiaobin ;

Zhang, Yajie .

MOLECULAR MEDICINE REPORTS, 2016, 13 (05) :3858-3866

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