One-Pot Biofunctionalization of Magnetic Nanoparticles via Thiol-Ene Click Reaction for Magnetic Hyperthermia and Magnetic Resonance Imaging

被引：77

作者：

Hayashi, Koichiro ^{[1
]}

Ono, Kenji ^{[2
]}

Suzuki, Hiromi ^{[2
]}

Sawada, Makoto ^{[2
]}

Moriya, Makoto ^{[1
]}

Sakamoto, Wataru ^{[1
]}

Yogo, Toshinobu ^{[1
]}

机构：

[1] Nagoya Univ, EcoTopia Sci Inst, Div Nanomat Sci, Chikusa Ku, Nagoya, Aichi 4648603, Japan

[2] Nagoya Univ, Environm Med Res Inst, Dept Brain Funct, Chikusa Ku, Nagoya, Aichi 4648601, Japan

来源：

CHEMISTRY OF MATERIALS | 2010年 / 22卷 / 12期

关键词：

CHEMISTRY; DESIGN;

D O I：

10.1021/cm100810g

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Cysteine-modified Fe3O4 nanoparticles (Cys-Fe3O4 NPs) were synthesized by the one-pot biofunctionalization of allyl-functionalized Fe3O4 NPs (allyl-Fe3O4) with cysteine using the in situ hydrolysis-condensation of iron(III) allylacetylacetonate and the thiol-ene click reaction. The particle size of Fe3O4 in Cys-Fe3O4 NPs measured by transmission electron microscopy and X-ray diffraction analysis was similar to 8 nm. Cys-Fe3O4 NPs were soluble in water and had a hydrodynamic diameter of 22 nm and prolonged stability in water. They were superparamagnetic, which was confirmed by fitting the Langevin equation to the magnetization data, generated heat in an alternating current (AC) magnetic field, and had a specific absorption rate (SAR) of 156 W g(-1) at 230 kHz and 100 Oe. In addition, they exhibited a T-2-weighted magnetic resonance imaging (MRI) contrast-enhancing effect.

引用

页码：3768 / 3772

页数：5

共 29 条

[1] Magnetic nanoparticles for drug delivery [J].

Arruebo, Manuel ;

Fernandez-Pacheco, Rodrigo ;

Ibarra, M. Ricardo ;

Santamaria, Jesus .

NANO TODAY, 2007, 2 (03) :22-32

[2] Synergistically Integrated Nanoparticles as Multimodal Probes for Nanobiotechnology [J].

Cheon, Jinwoo ;

Lee, Jae-Hyun .

ACCOUNTS OF CHEMICAL RESEARCH, 2008, 41 (12) :1630-1640

[3]

Chikazumi S., 1997, PHYS FERROMAGNETISM, V2nd

[4] Recent advances in iron oxide nanocrystal technology for medical imaging [J].

Corot, Claire ;

Robert, Philippe ;

Idee, Jean-Marc ;

Port, Marc .

ADVANCED DRUG DELIVERY REVIEWS, 2006, 58 (14) :1471-1504

[5]

DAY ES, 2009, ASME, V131

[6] The defining length scales of mesomagnetism: A review [J].

Dennis, CL ;

Borges, RP ;

Buda, LD ;

Ebels, U ;

Gregg, JF ;

Hehn, M ;

Jouguelet, E ;

Ounadjela, K ;

Petej, I ;

Prejbeanu, IL ;

Thornton, MJ .

JOURNAL OF PHYSICS-CONDENSED MATTER, 2002, 14 (49) :R1175-R1262

[7] The Emergence of Thiol-Ene Coupling as a Click Process for Materials and Bioorganic Chemistry [J].

Dondoni, Alessandro .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (47) :8995-8997

[8] Magnetic colloids as drug vehicles [J].

Duran, J. D. G. ;

Arias, J. L. ;

Gallardo, V. ;

Delgado, A. V. .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 97 (08) :2948-2983

[9] Optimizing magnetic nanoparticle design for nanothermotherapy [J].

Gazeau, Florence ;

Levy, Michael ;

Wilhelm, Claire .

NANOMEDICINE, 2008, 3 (06) :831-844

[10] MODIFICATION OF CELL LETHALITY AT ELEVATED-TEMPERATURES - PH EFFECT [J].

GERWECK, LE .

RADIATION RESEARCH, 1977, 70 (01) :224-235

← 1 2 3 →