共 32 条
The physicochemical basis of the biological activity and pharmacological properties of the antiviral agent Panavir
被引:3
作者:
Stovbun, S. V.
[1
]
Yakovenko, L. V.
[2
]
机构:
[1] Russian Acad Sci, NN Semenov Chem Phys Inst, Moscow 119991, Russia
[2] Moscow MV Lomonosov State Univ, Dept Phys, Moscow 119991, Russia
关键词:
Panavir;
soft nanoparticles;
antiviral effect;
cell membrane;
cytoskeleton;
activation of immune cells;
POLYSACCHARIDE;
NANOPARTICLES;
D O I:
10.3103/S0027134914060150
中图分类号:
O4 [物理学];
学科分类号:
0702 ;
摘要:
The agent Panavir possesses versatile antiviral, anti-inflammatory, and analgesic effects, which still have not been explained at the molecular level. Here, we propose a simple physicochemical model of Panavir nanoparticles, which allows one to explain its effects by the mechanical activation of cells, including those of the immune system. Thus, there is no need for binding of the Panavir particles to any supramolecular chiral receptor for manifestation of its all known effects.
引用
收藏
页码:542 / 547
页数:6
相关论文