Cleft lip and palate

被引：0
作者：
Voigt, A. [1 ]
Radlanski, R. J. [2 ]
Sarioglu, N. [3 ]
Schmidt, G. [1 ]
机构：
[1] Charite Campus Virchow, Klin Mund, Arbeitsbereich Lippen, Kiefer,Gaumen Spalten,Kiefer,Gesichts Chirurg, Augustenburger Pl 1, D-13353 Berlin, Germany
[2] Charite Campus Benjamin Franklin, Inst Orale Strukt & Entwicklungsbiol, Berlin, Germany
[3] Charite Campus Mitte, Inst Pathol, Arbeitsbereich Paidopathol & Plazentol, Berlin, Germany
来源：
PATHOLOGE | 2017年 / 38卷 / 04期
关键词：
Syndromic; Non-syndromic cleft lip and palate; Paidopathological aspects; Robin sequence; Sucking disorder; ORAL CLEFTS; ASSOCIATION; DIAGNOSIS; GENETICS; TGFB3; MSX1;
D O I：
10.1007/s00292-017-0313-x
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Cleft lip and palate (CLP) represents a group of malformations of unknown etiology but similar phenotypes. This implies consequences for the diagnostics, therapy, prevention, prognosis and risk estimation. Definition of CLP subtypes and the embryonic development, clarification of correlations and differences between entities using epidemiological data, overview of the present state of genetic analyses, correlation to syndromes, sequences and associations and resulting consequences for clinical practice. Update on embryological development of the face, summary of epidemiological and genetic studies and considerations on pedopathological and forensic aspects. Syndromic and non-syndromic CLP exhibit different and highly variable etiologies, therapeutic needs and prognosis. A thorough understanding is mandatory to distinguish between the different subgroups. In addition to specific aspects of CLP for the pediatric (forensic) pathologist this article provides an overall view of the topic which aims to help understand these malformations.
引用
收藏
页码：241 / 247
页数：7
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