Magterpenoids A-C, Three Polycyclic Meroterpenoids with PTP1B Inhibitory Activity from the Bark of Magnolia officinalis var. biloba

被引：41

作者：

Li, Chuan

Li, Chuang-Jun

Ma, Jie

Chen, Fang-You

Li, Li

Wang, Xiao-Liang

Ye, Fei

Zhang, Dong-Ming ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Substance & Funct Nat Med, Beijing 100050, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 12期

关键词：

HONOKIOL; CELLS; EXPRESSION;

D O I：

10.1021/acs.orglett.8b01476

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Magterpenoid A (1), possessing a rare 4,6,11-trioxatricyclo[5.3.1.0(1,5)]undecane framework with an irregular monoterpenoid moiety, magterpenoid B (2), with an unprecedented 6/6/6/6 polycyclic skeleton, and magterpenoid C (3), a novel terpenoid quinone with a C6-C3 unit, were isolated from the bark of Magnolia officinalis var. biloba. Plausible biogenetic pathways of 1-3 are presented. Compounds 1 and 3 exhibited significant PTP1B inhibitory activities with IC50 values of 1.44 and 0.81 mu M, respectively.

引用

页码：3682 / 3686

页数：5

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