Examining the Cardiac NK-2 Genes in Early Heart Development

被引：41
作者：
Bartlett, Heather [2 ]
Veenstra, Gert Jan C. [3 ]
Weeks, Daniel L. [1 ]
机构：
[1] Univ Iowa, Dept Biochem, Iowa City, IA 52242 USA
[2] Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA
[3] Radboud Univ Nijmegen, Dept Mol Biol, Fac Sci, Nijmegen Ctr Mol Life Sci, NL-6525 ED Nijmegen, Netherlands
来源：
PEDIATRIC CARDIOLOGY | 2010年 / 31卷 / 03期
关键词：
Abnormal heart formation; Cardiac NK-2 genes; Cardiac NK-2 transcription factors; Congenital heart disease; Early heart development; TINMAN-RELATED GENES; XENOPUS EMBRYOS; HOMEOBOX GENES; CSX/NKX2.5; HOMEOPROTEIN; MUTUAL COFACTORS; NKX2-5; EXPRESSION; TRANSCRIPTION; DIFFERENTIATION; MUTATIONS;
D O I：
10.1007/s00246-009-9605-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The cardiac NK-2 transcription factors are the vertebrate relatives of the Drosophila tinman gene. Without the Drosophila tinman gene, fruit flies fail to form their heart ("dorsal vessel"), and mutations or altered expression of cardiac NK-2 genes may lead to abnormal heart formation in vertebrates. Although the cardiac NK-2 gene NKX2-5 is recognized as an important factor in cases of human congenital heart disease and heart development in vertebrates, the roles of the other cardiac NK-2 genes are less clear. This report reviews what is known about the cardiac NK-2 genes in cardiac development, comparing studies in several different model systems.
引用
收藏
页码：335 / 341
页数：7
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