Real-time monitoring of cellular integration within bulk soft tissue scaffold materials

被引：3
作者：
Pavey, KD
James, SL
James, SE
Mikhalovska, LI
Tomlins, P
Paul, F
Mikhalovsky, SV
机构：
[1] Univ Brighton, Sch Pharm & Biomol Sci, Brighton BN2 4GJ, E Sussex, England
[2] Natl Phys Lab, Mat Ctr, Teddington TW11 0LW, Middx, England
[3] GlaxoSmithKline, NFSP N, Technol Dev Grp, Harlow CM19 5AW, Essex, England
[4] Queen Victoria Hosp, Blond McIndoe Res Ctr, E Grinstead RH19 3DZ, W Sussex, England
来源：
JOURNAL OF MATERIALS CHEMISTRY | 2003年 / 13卷 / 04期
关键词：
D O I：
10.1039/b300989k
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A non-invasive, real-time acoustic method for the monitoring of cellular integration within commercial collagen-based dermal replacement scaffolds is reported for the first time. An unexpectedly high degree of acoustic energy transfer through heavily hydrated thick film (up to 0.5 mm) sections of collagen/glycosaminoglycan scaffold material intimately associated with a quartz crystal sensor allowed quantitative resonant frequency measurements upon application of fibroblast cell suspensions to the material. Changes in resonant frequency and energy dissipation were commensurate with cellular interaction with the gel.
引用
收藏
页码：654 / 656
页数：3
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