Aminoglycoside-induced deafness during treatment of acute leukaemia

被引：5

作者：

Bitner-Glindzicz, M. ^{[1
,3
]}

Osei-Lah, V. ^{[2
,4
]}

Colvin, I. ^{[5
]}

Sirimanna, T. ^{[2
]}

Lucas, D. ^{[5
]}

Mac Ardle, B. ^{[5
]}

Webb, D. ^{[6
]}

Shankar, A. ^{[7
]}

Kingston, J. ^{[6
]}

Jenkins, L. ^{[8
]}

Rahman, S. ^{[1
,9
]}

机构：

[1] UCL, Inst Child Hlth, Clin & Mol Genet Unit, London WC1N 1EH, England

[2] Great Ormond St Hosp Sick Children, Dept Audiol Med, London WC1N 3JH, England

[3] UCL, Ear Inst, London WC1N 1EH, England

[4] Queen Alexandra Hosp, Dept Audiol Med, Portsmouth, Hants, England

[5] Royal Natl Throat Nose & Ear Hosp, Nuffield Hearing & Speech Ctr, London WC1X 8DA, England

[6] Great Ormond St Hosp Sick Children, Dept Haematol & Oncol, London WC1N 3JH, England

[7] Royal London Hosp, Dept Paediat Haematol & Oncol, London E1 1BB, England

[8] Great Ormond St Hosp Sick Children, N Thames E Reg Clin Mol Genet Lab, London WC1N 3JH, England

[9] Natl Hosp Neurol & Neurosurg, MRC, Ctr Neuromuscular Dis, London WC1N 3BG, England

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 2010年 / 95卷 / 02期

关键词：

HEARING-LOSS; MITOCHONDRIAL; MUTATION; CHILDREN;

D O I：

10.1136/adc.2009.158220

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Three unrelated children from ethnically diverse backgrounds who were treated for acute leukaemia became profoundly and irreversibly deaf during treatment. Aminoglycoside levels were within the therapeutic range. Genetic testing showed all three to have a maternally inherited mutation of mitochondrial DNA, m. 1555A>G, known to cause sensitivity to the ototoxic effects of aminoglycosides. One child has received a cochlear implant, and another will be implanted shortly. Children diagnosed with acute leukaemia should be tested for this mutation at diagnosis, and alternative antibiotics chosen for the treatment of sepsis. Consideration should be given to elective testing of other groups of patients likely to receive aminoglycosides.

引用

页码：153 / 155

页数：3

共 6 条

[1] Hearing-impaired children in the United Kingdom, II: Cochlear implantation and the cost of compulsory education [J].

Barton, GR ;

Stacey, PC ;

Fortnum, HM ;

Summerfield, AQ .

EAR AND HEARING, 2006, 27 (02) :187-207

[2] Prevalence of Mitochondrial 1555A>G Mutation in European Children [J].

Bitner-Glindzicz, Maria ;

Pembrey, Marcus ;

Duncan, Andrew ;

Heron, Jon ;

Ring, Susan M. ;

Hall, Amanda ;

Rahman, Shamima .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (06) :640-642

[3] Ototoxicity caused by aminoglycosides [J].

Bitner-Glindzicz, Maria ;

Rahman, Shamima .

BMJ-BRITISH MEDICAL JOURNAL, 2007, 335 (7624) :784-785

[4] Mitochondrial deafness alleles confer misreading of the genetic code [J].

Hobbie, Sven N. ;

Bruell, Christian M. ;

Akshay, Subramanian ;

Kalapala, Sarath K. ;

Shcherbakov, Dmitry ;

Boettger, Erik C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (09) :3244-3249

[5] Mutational analysis of the mitochondrial 12S rRNA gene in Chinese pediatric subjects with aminoglycoside-induced and non-syndromic hearing loss [J].

Li, ZY ;

Li, RH ;

Chen, JF ;

Liao, Z ;

Zhu, Y ;

Qian, YP ;

Xiong, SD ;

Heman-Ackah, S ;

Wu, JB ;

Choo, DI ;

Guan, MX .

HUMAN GENETICS, 2005, 117 (01) :9-15

[6] Sensorineural hearing loss caused by mitochondrial DNA mutations: Special reference to the A1555G mutation [J].

Usami, SI ;

Abe, S ;

Shinkawa, H ;

Kimberling, WJ .

JOURNAL OF COMMUNICATION DISORDERS, 1998, 31 (05) :423-435

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