Expression and function of stress (heat shock) proteins in gastrointestinal tract

被引：11

作者：

Otaka, Michiro ^{[1
]}

Odashima, Masaru ^{[1
]}

Tamaki, Kumiko ^{[1
]}

Watanabe, Sumio ^{[1
]}

机构：

[1] Juntendo Univ, Sch Med, Dept Gastroenterol, Bunkyo Ku, Tokyo 1138421, Japan

来源：

INTERNATIONAL JOURNAL OF HYPERTHERMIA | 2009年 / 25卷 / 08期

关键词：

heat shock protein; molecular chaperone; stress; cytoprotection; stomach; intestine; colon; HSP-binding protein; L-CARNOSINE PROTECTS; ACID-INDUCED COLITIS; RAT GASTRIC-MUCOSA; ISCHEMIA/REPERFUSION INJURY; MOLECULAR CHAPERONES; INDUCTION; GERANYLGERANYLACETONE; HEAT-SHOCK-PROTEIN-25; PREINDUCTION; CELLS;

D O I：

10.3109/02656730903315815

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This review will focus on gastrointestinal mucosal protection against cytotoxic agents and cellular stress mainly from the viewpoint of expression and function of heat shock proteins, in their role of 'molecular chaperones', as internal cytoprotectants. Also, recently identified target molecules of heat shock protein in damaged gastric mucosal cells are introduced. Elucidation of such stress-responses and repairing process of damaged protein by heat shock proteins in the gastrointestinal mucosa may provide a better understanding for the mechanisms of cytoprotection and cellular repair. In addition, these findings in post-genomic level may provide new strategies for the therapy of gastrointestinal disorders.

引用

页码：634 / 640

页数：7

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