In vitro potential antiviral SARS-CoV-19-activity of natural product thymohydroquinone and dithymoquinone from Nigella sativa

被引：43
作者：
Esharkawy, Eman R. [1 ]
Almalki, Faisal [2 ]
Ben Hadda, Taibi [2 ,3 ]
机构：
[1] Northern Border Univ, Coll Sci, Dept Chem, Ar Ar, Saudi Arabia
[2] Umm Al Qura Univ, Fac Pharm, Dept Pharmaceut Chem, Mecca 21955, Saudi Arabia
[3] Mohammed Premier Univ, Fac Sci, Lab Appl Chem & Environm, MB 524, Oujda 60000, Morocco
来源：
BIOORGANIC CHEMISTRY | 2022年 / 120卷
关键词：
Antiviral; SARSCoV-19; Thymoquinone; Dithymoquinone; Hydrothymoquinone; POM ANALYSES; ANTIMICROBIAL ACTIVITY; COMPUTATIONAL POM; CRYSTAL-STRUCTURE; THYMOQUINONE; DERIVATIVES; DFT; IDENTIFICATION; ANTIBACTERIAL; BIOACTIVITY;
D O I：
10.1016/j.bioorg.2021.105587
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inflammation, oxidation, and compromised immunity all increase the dangers of COVID-19, whereas many pharmaceutical protocols may lead to increased immunity such as ingesting from sources containing vitamin E and zinc. A global search for natural remedies to fight COVID-19 has emerged, to assist in the treatment of this infamous coronavirus. Nigella satvia is a world-renowned plant, an esteemed herbal remedy, which can be used as a liquid medicine to increase immunity while decreasing the dangers of acute respiratory distress syndrome. Thymoqinone (TQ), dithymoqinone (DTQ) and thymohydroquinone (THQ), are major compounds of the essential oil contained in N.sativa. A current study aims to discover the antiviral activity of two compounds, Thymohydroquinone and Dithymoquinone, which are synthesized through simple chemical procedures, deriving from thymoquinone, which happens to be a major compound of Nigella sativa. A half-maximal cytotoxic concentration, "CC50 ", was calculated by MTT assay for each individual drug, The sample showed anti-SARS-CoV-2 activity at non-cytotoxic nanomolar concentrations in vitro with a low selectivity index (CC50/IC50 = 31.74/ 23.15 = 1.4), whereby Dimthymoquinone shows high cytotoxicity.
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