Carcinogenesis: A balance between beta-catenin and APC

被引：96
作者：
Gumbiner, BM
机构：
来源：
CURRENT BIOLOGY | 1997年 / 7卷 / 07期
关键词：
D O I：
10.1016/S0960-9822(06)00214-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A protein first identified by its association with cadherin cell adhesion molecules, beta-catenin, has been implicated in carcinogenesis. In a number of different types of cancer, signalling through beta-catenin is upregulated either by direct mutation of beta-catenin or loss of negative regulation by the APC tumor suppressor protein.
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页码：R443 / R446
页数：4
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