Prognostic value of serum IL-17 and VEGF levels in small cell lung cancer

被引：28
作者：
Lin, Qunying [1 ]
Xue, Lei [2 ]
Tian, Tian [3 ,4 ]
Zhang, Bo [3 ,4 ,5 ]
Guo, Lijing [1 ]
Lin, Guosheng [1 ]
Chen, Zhiwei [1 ]
Fan, Kexing [3 ,4 ,5 ]
Gu, Xiaobin [3 ,4 ]
机构：
[1] Putian Univ, Affiliated Hosp, Dept Resp Med, Putian, Fujian, Peoples R China
[2] Second Mil Med Univ, Changzheng Hosp, Dept Thorac Surg, Shanghai 200433, Peoples R China
[3] Chinese Peoples Liberat Army Gen Hosp, Ctr Canc, Beijing 100853, Peoples R China
[4] Chinese PLA Med Sch, Beijing, Peoples R China
[5] Second Mil Med Univ, Int Joint Canc Inst, 800 Xiang Yin Rd,New Bldg West 10-11th Floor, Shanghai 200433, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS | 2015年 / 30卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Interleukin-17; Prognosis; Small cell lung cancer; Vascular endothelial growth factor; ENDOTHELIAL GROWTH-FACTOR; EXPRESSION; FOXP3; IL17;
D O I：
10.5301/jbm.5000148
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Objective: To explore the prognostic value of serum interleukin-17 (IL-17) and vascular endothelial growth factor (VEGF) levels in patients with small cell lung cancer (SCLC). Materials and Methods: IL-17 and VEGF levels were determined by a commercially available ELISA method. Results: Serum IL-17 and VEGF levels were higher in the SCLC group than the control group (p<0.001 and p<0.0001, respectively). In addition, there was a significant correlation between IL-17 and VEGF. The level of IL-17 showed significant correlations with tumor stage and tumor metastasis, while serum VEGF levels were significantly associated only with tumor metastasis. Univariate and multivariate analysis indicated that an elevated IL-17 level was an independent prognostic factor for shorter overall survival in SCLC. Conclusions: IL-17 may play an important role in tumor dissemination in SCLC patients and measurement of IL-17 could have useful prognostic value for worse overall survival in patients with SCLC.
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收藏
页码：E359 / E363
页数：5
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