Enantioselective Conjugate Addition of Aryl Halides and Triflates to Electron-Deficient Olefins via Nickel- and Rhodium-Catalyzed Sequential Relay Reactions

被引：5
|
作者：
Fan, Chenrui [1 ]
Wu, Qixu [1 ]
Zhu, Chengfeng [1 ]
Wu, Xiang [1 ]
Li, Yougui [1 ]
Luo, Yunfei [1 ]
He, Jian-Bo [1 ]
机构：
[1] Hefei Univ Technol, Sch Chem & Chem Engn, Anhui Prov Key Lab Adv Catalyt Mat & React Engn, Hefei 230009, Anhui, Peoples R China
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 22期
关键词：
C-H FUNCTIONALIZATION; CHIRAL DIENE LIGANDS; ASYMMETRIC 1,4-ADDITION; ALPHA; BETA-UNSATURATED CARBONYL; ARYLBORONIC ACIDS; DERIVATIVES; BORYLATION; ARYLATION; REAGENTS; COMPLEX;
D O I：
10.1021/acs.orglett.9b02940
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Asymmetric conjugate addition of aryl halides or aryl triflates to electron-deficient olefins was realized by sequential Miyaura borylation and Hayashi-Miyaura conjugate addition in one pot. A nickel-catalyzed borylation of aryl halides or triflates and a rhodium-chiral diene complex catalyzed enantioselective conjugate addition was executed as a pair of relay reactions as a more efficient and greener protocol.
引用
收藏
页码：8888 / 8892
页数：5
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