Enantioselective Conjugate Addition of Aryl Halides and Triflates to Electron-Deficient Olefins via Nickel- and Rhodium-Catalyzed Sequential Relay Reactions

被引：5

作者：

Fan, Chenrui ^{[1
]}

Wu, Qixu ^{[1
]}

Zhu, Chengfeng ^{[1
]}

Wu, Xiang ^{[1
]}

Li, Yougui ^{[1
]}

Luo, Yunfei ^{[1
]}

He, Jian-Bo ^{[1
]}

机构：

[1] Hefei Univ Technol, Sch Chem & Chem Engn, Anhui Prov Key Lab Adv Catalyt Mat & React Engn, Hefei 230009, Anhui, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 22期

关键词：

C-H FUNCTIONALIZATION; CHIRAL DIENE LIGANDS; ASYMMETRIC 1,4-ADDITION; ALPHA; BETA-UNSATURATED CARBONYL; ARYLBORONIC ACIDS; DERIVATIVES; BORYLATION; ARYLATION; REAGENTS; COMPLEX;

D O I：

10.1021/acs.orglett.9b02940

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric conjugate addition of aryl halides or aryl triflates to electron-deficient olefins was realized by sequential Miyaura borylation and Hayashi-Miyaura conjugate addition in one pot. A nickel-catalyzed borylation of aryl halides or triflates and a rhodium-chiral diene complex catalyzed enantioselective conjugate addition was executed as a pair of relay reactions as a more efficient and greener protocol.

引用

页码：8888 / 8892

页数：5

共 40 条

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