CpG-DNA as immune response modifier

被引：31
作者：
Dalpke, AH
Heeg, K
机构：
[1] Heidelberg Univ, Dept Hyg & Med Microbiol, Inst Hyg, D-69120 Heidelberg, Germany
[2] Univ Marburg, Inst Med Microbiol & Hyg, D-35037 Marburg, Germany
来源：
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2004年 / 294卷 / 05期
关键词：
CpG-DNA; immunopharmacology; innate immunity; toll-like receptor; sequence motifs;
D O I：
10.1016/j.ijmm.2004.07.005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Toll-like receptors (TLRs) have been recognized to play a fundamental role in the recognition of microbial pathogens and the activation of innate immunity. However, it has also turned out that triggering of TLRs with purified compounds or synthetic ligands represents a powerful means to modulate innate as well as adaptive immune responses. Among the substances currently under investigation as immune response modifiers CpG-DNA has gained particular interest. One reason for this is the feasibility to easily synthesize and modify immunostimulatory CpG-containing oligodeoxynucleotides (CpG-ODNs). This review deals with the structural needs of CpG-ODNs. CpG-ODNs are discussed as being composed of distinct building blocks (e.g. sequence strings, backbone modifications) giving rise to a concept of structural modules within CpG-ODNs. (C) 2004 Elsevier GmbH. All rights reserved.
引用
收藏
页码：345 / 354
页数：10
相关论文
共 67 条
[11]  
Dalpke A, 2002, CRIT REV IMMUNOL, V22, P217
[12]   Phosphodiester CpG oligonucleotides as adjuvants:: polyguanosine runs enhance cellular uptake and improve immunostimulative activity of phosphodiester CpG oligonucleotides in vitro and in vivo [J].
Dalpke, AH ;
Zimmermann, S ;
Albrecht, I ;
Heeg, K .
IMMUNOLOGY, 2002, 106 (01) :102-112
[13]  
Deng GM, 2000, INT J MOL MED, V6, P29
[14]   Strong cytosine-guanosine-independent immunostimulation in humans and other primates by synthetic oligodeoxynucleotides with PyNTTTTGT motifs [J].
Elias, F ;
Flo, J ;
Lopez, RA ;
Zorzopulos, J ;
Montaner, A ;
Rodriguez, JM .
JOURNAL OF IMMUNOLOGY, 2003, 171 (07) :3697-3704
[15]  
Gao JJ, 1999, J IMMUNOL, V163, P4095
[16]  
Gao JJ, 2002, J LEUKOCYTE BIOL, V72, P1234
[17]   Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6 [J].
Häcker, H ;
Vabulas, RM ;
Takeuchi, O ;
Hoshino, K ;
Akira, S ;
Wagner, H .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (04) :595-600
[18]   CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation [J].
Häcker, H ;
Mischak, H ;
Miethke, T ;
Liptay, S ;
Schmid, R ;
Sparwasser, T ;
Heeg, K ;
Lipford, GB ;
Wagner, H .
EMBO JOURNAL, 1998, 17 (21) :6230-6240
[19]   Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-α induction in plasmacytoid dendritic cells [J].
Hartmann, G ;
Battiany, J ;
Poeck, H ;
Wagner, M ;
Kerkmann, M ;
Lubenow, N ;
Rothenfusser, S ;
Endres, S .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (06) :1633-1641
[20]   Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo [J].
Hartmann, G ;
Weeratna, RD ;
Ballas, ZK ;
Payette, P ;
Blackwell, S ;
Suparto, I ;
Rasmussen, WL ;
Waldschmidt, M ;
Sajuthi, D ;
Purcell, RH ;
Davis, HL ;
Krieg, AM .
JOURNAL OF IMMUNOLOGY, 2000, 164 (03) :1617-1624
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